Phenampromide

Base Information

• Chemical Name: Phenampromide
• CAS No.: 129-83-9
• Molecular Formula: C₁₇H₂₆N₂O
• Molecular Weight: 274.406
• Hs Code.: 2933399078
• European Community (EC) Number: 204-967-1
• UNII: 0600L2M6EZ
• DSSTox Substance ID: DTXSID10911012
• Nikkaji Number: J10.046C
• Wikipedia: Phenampromide
• Wikidata: Q7181329
• NCI Thesaurus Code: C66367
• ChEMBL ID: CHEMBL2104589
• Mol file: 129-83-9.mol

Synonyms:Phenampromide;Phenampromid;129-83-9;Fenampromide [DCIT];Fenampromida;Fenampromide;Phenampromidum;Phenampromide [INN:BAN];Fenampromida [INN-Spanish];Phenampromidum [INN-Latin];N-(1-Methyl-2-piperidinoethyl)propionanilide;EINECS 204-967-1;PROPIONANILIDE, N-(1-METHYL-2-PIPERIDINOETHYL)-;UNII-0600L2M6EZ;IDS-NP-019;DEA No. 9638;0600L2M6EZ;N-phenyl-N-(1-piperidin-1-ylpropan-2-yl)propanamide;Propanamide, N-(1-methyl-2-(1-piperidinyl)ethyl)-N-phenyl-;Phenampromid(e);Propanamide, N-[1-methyl-2-(1-piperidinyl)ethyl]-N-phenyl-;Phenampromide [BAN:INN];PHENAMPROMIDE [MI];PHENAMPROMIDE [INN];N-[1-Methyl-2-(1-piperidinyl)ethyl]-N-phenylpropanamide;Propanamida, N-[1-metil-2-(1-piperidinil)etil]-N-fenil-;SCHEMBL907886;CHEMBL2104589;DTXSID10911012;LS-124430;Q7181329;N-[1-Methyl-2-(1-piperidinyl)ethyl]-N-phenylpropanamide #;N-(1-METHYL-2-PIPERIDIN-1-YLETHYL)-N-PHENYLPROPANAMIDE

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Chemical Property of Phenampromide

Chemical Property:

• Vapor Pressure: 2.11E-06mmHg at 25°C
• Refractive Index: nD28 1.518
• Boiling Point: 393.6°Cat760mmHg
• Flash Point: 155.5°C
• PSA: 23.55000
• Density: 1.037g/cm³
• LogP: 3.24190
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 274.204513457
• Heavy Atom Count: 20
• Complexity: 293

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)N(C1=CC=CC=C1)C(C)CN2CCCCC2

Technology Process of Phenampromide

There total 10 articles about Phenampromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(R)-N-(1-(piperidin-1-yl)propan-2-yl)aniline (722-02-1,93761-77-4) + propionyl chloride (79-03-8) → (R)-N-phenyl-N-(1-(piperidin-1-yl)propan-2-yl)propionamide (129-83-9,668-38-2)

Guidance literature:

With potassium carbonate; In toluene; at 0 ℃; for 4h;

DOI:10.1016/j.tetasy.2017.06.001

Reference yield:

N-Benzylaniline (758640-21-0,103-32-2) → (R)-N-phenyl-N-(1-(piperidin-1-yl)propan-2-yl)propionamide (129-83-9,668-38-2)

Guidance literature:

Multi-step reaction with 6 steps

1: methanol / 24 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 6.5 h / 0 °C / Reflux

3: triethylamine / dichloromethane / 2 h / 0 - 10 °C

4: triethylamine / toluene / 8 h / Reflux

5: palladium(II) hydroxide; hydrogen / methanol / 6 h / 3102.97 Torr

6: potassium carbonate / toluene / 4 h / 0 °C

With lithium aluminium tetrahydride; hydrogen; palladium(II) hydroxide; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene;

DOI:10.1016/j.tetasy.2017.06.001

Reference yield:

(S)-1-(benzyl(phenyl)amino)propan-2-ol → (R)-N-phenyl-N-(1-(piperidin-1-yl)propan-2-yl)propionamide (129-83-9,668-38-2)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / 0 - 10 °C

2: triethylamine / toluene / 8 h / Reflux

3: palladium(II) hydroxide; hydrogen / methanol / 6 h / 3102.97 Torr

4: potassium carbonate / toluene / 4 h / 0 °C

With hydrogen; palladium(II) hydroxide; potassium carbonate; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1016/j.tetasy.2017.06.001

upstream raw materials:

propionic acid anhydride

N-Benzylaniline

(R)-N-(1-(piperidin-1-yl)propan-2-yl)aniline

propionyl chloride

Refernces