6-Benzyloxygramine

Base Information

Chemical Name:6-Benzyloxygramine
CAS No.:57765-22-7
Molecular Formula:C18H20N2O
Molecular Weight:280.36
Hs Code.:2933990090
NSC Number:92545
DSSTox Substance ID:DTXSID80293837
Nikkaji Number:J2.419.119B
Wikidata:Q82032809
Mol file:57765-22-7.mol

Synonyms:6-Benzyloxygramine;57765-22-7;1-(6-(Benzyloxy)-1H-indol-3-yl)-N,N-dimethylmethanamine;N,N-dimethyl-1-(6-phenylmethoxy-1H-indol-3-yl)methanamine;6-BENZYLOXY-3-(DIMETHYLAMINOMETHYL)INDOLE;NSC92545;(6-Benzyloxyindolyl)-N,N-dimethylmethylamine;SCHEMBL274611;DTXSID80293837;ARPLSLHBKDIBNO-UHFFFAOYSA-N;NSC-92545;AKOS005259117;CS-16532;CS-0099815;FT-0640482;B-1520;D76031

Suppliers and Price of 6-Benzyloxygramine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Benzyloxygramine
250mg
$ 1050.00

TRC
6-Benzyloxygramine
50mg
$ 270.00

Biosynth Carbosynth
6-Benzyloxygramine
25 mg
$ 227.50

Biosynth Carbosynth
6-Benzyloxygramine
50 mg
$ 413.50

Biosynth Carbosynth
6-Benzyloxygramine
100 mg
$ 751.00

Biosynth Carbosynth
6-Benzyloxygramine
250 mg
$ 1365.00

Biosynth Carbosynth
6-Benzyloxygramine
10 mg
$ 125.10

American Custom Chemicals Corporation
6-BENZYLOXYGRAMINE 95.00%
250MG
$ 1732.50

American Custom Chemicals Corporation
6-BENZYLOXYGRAMINE 95.00%
25MG
$ 721.88

AK Scientific
6-Benzyloxygramine
25mg
$ 357.00

Total 11 raw suppliers

Chemical Property of 6-Benzyloxygramine

Chemical Property:

Vapor Pressure:5.06E-08mmHg at 25°C
Melting Point:134-136?C
Refractive Index:1.639
Boiling Point:442.3 °C at 760 mmHg
Flash Point:221.3 °C
PSA：28.26000
Density:1.153 g/cm³
LogP:3.80850
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:280.157563266
Heavy Atom Count:21
Complexity:314

Purity/Quality:

98%min ^*data from raw suppliers

6-Benzyloxygramine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CC1=CNC2=C1C=CC(=C2)OCC3=CC=CC=C3
Uses A benzyloxyindole derivative as PPARγ agonist.

Technology Process of 6-Benzyloxygramine

There total 8 articles about 6-Benzyloxygramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 15903-94-3
6-benzyloxy-1H-indole

: 124-40-3
dimethyl amine

: 57765-22-7
3-(dimethylaminomethyl)-6-benzyloxyindole

Guidance literature:: With acetic acid;
DOI:10.1016/j.bmcl.2006.06.093

Reference yield: 54.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 15903-94-3
6-benzyloxy-1H-indole

: 506-59-2
N,N-dimethylammonium chloride

: 57765-22-7
3-(dimethylaminomethyl)-6-benzyloxyindole

Guidance literature:: With acetic acid; triethylamine; In 1,4-dioxane; water; at 40 ℃; for 20h;
DOI:10.1021/acs.joc.9b00039

Reference yield:

: (E)-2-Azido-3-(4-benzyloxy-phenyl)-acrylic acid ethyl ester

: 57765-22-7
3-(dimethylaminomethyl)-6-benzyloxyindole

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / xylene / Heating

2: 91 percent / aq. NaOH / ethanol / Heating

3: 82 percent / Cu; quinoline / Heating

4: 91 percent / CH₃COOH

With quinoline; sodium hydroxide; copper; acetic acid; In ethanol; xylene; 4: Mannich reaction;
DOI:10.1016/j.bmcl.2006.06.093