Technology Process of Carbamic acid,
[[(2R,4R)-2-(1,1-dimethylethyl)-5-oxo-4-(phenylmethyl)-1,3-dioxolan-4-yl
]methyl]-, methyl ester
There total 3 articles about Carbamic acid,
[[(2R,4R)-2-(1,1-dimethylethyl)-5-oxo-4-(phenylmethyl)-1,3-dioxolan-4-yl
]methyl]-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-((2R,4R)-2-tert-butyl-4-benzyl-5-oxo-1,3-dioxolan-4-yl)acetic acid;
With
diphenyl-phosphinic acid; triethylamine;
In
toluene;
at 20 ℃;
for 1h;
methanol;
In
toluene;
for 16h;
Heating;
DOI:10.1016/j.tetasy.2006.11.033
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 98 percent / p-toluenesulfonic acid; H2SO4 / pentane / 36 h / Heating
2.1: 81 percent / LHMDS / tetrahydrofuran / 6.5 h / -78 - -23 °C
3.1: DPPA; Et3N / toluene / 1 h / 20 °C
3.2: 85 percent / toluene / 16 h / Heating
With
sulfuric acid; diphenyl-phosphinic acid; toluene-4-sulfonic acid; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene; pentane;
3.1: Curtius rearrangement;
DOI:10.1016/j.tetasy.2006.11.033
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 81 percent / LHMDS / tetrahydrofuran / 6.5 h / -78 - -23 °C
2.1: DPPA; Et3N / toluene / 1 h / 20 °C
2.2: 85 percent / toluene / 16 h / Heating
With
diphenyl-phosphinic acid; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
2.1: Curtius rearrangement;
DOI:10.1016/j.tetasy.2006.11.033
