1H-Pyrrolo[2,3-b]pyridine-3-ethanol

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine-3-ethanol
• CAS No.: 90929-76-3
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.191
• European Community (EC) Number: 838-210-7
• Mol file: 90929-76-3.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridine-3-ethanol;90929-76-3;2-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanol;2-(1H-Pyrrolo[2,3-b]pyridin-3-yl)ethan-1-ol;2-{1h-pyrrolo[2,3-b]pyridin-3-yl}ethan-1-ol;starbld0046528;SCHEMBL2437619;MNELAFNGGZMCMI-UHFFFAOYSA-N;EN300-1869342

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-3-ethanol

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 162.079312947
• Heavy Atom Count: 12
• Complexity: 152

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(NC=C2CCO)N=C1

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-3-ethanol

There total 1 articles about 1H-Pyrrolo[2,3-b]pyridine-3-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxirane (75-21-8,99932-75-9) + 3-bromo-1H-pyrrolo[2,3-b]pyridine (74420-15-8) → 7-Azaindole (271-63-6) + 1-(2-hydroxyethyl)-7-azaindole (90929-77-4) + 3-(2-hydroxyethyl)-7-azaindole (90929-76-3)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction. Yields of byproduct given; 1.) ether, 1,2-dimethoxyethane, -5 deg C, 1 h; 2.) 0 deg C, 5 h;

Reference yield: 64.2%

4-benzyl-4-morpholin-4-ylcyclohexanone (1002916-45-1) + 3-(2-hydroxyethyl)-7-azaindole (90929-76-3) → 4-benzyl-4-morpholino-spiro[cyclohexane-1,8'-(5,6,8,9-tetrahydropyrano[3,4-b]-7-azaindole)] (1002916-07-5)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 240h;

Reference yield: 62.0%

4-dimethylamino-4-phenylcyclohexanone (65619-20-7) + 3-(2-hydroxyethyl)-7-azaindole (90929-76-3) → 4-(dimethylamino)-4-phenyl-spiro[cyclohexane-1,8'-(5,6,8,9-tetrahydropyrano[3,4-b]-7-azaindole)] (1002915-80-1)

Guidance literature:

4-dimethylamino-4-phenylcyclohexanone; 3-(2-hydroxyethyl)-7-azaindole; With trifluorormethanesulfonic acid; In dichloromethane; at 20 ℃; for 20h;

With sodium hydroxide; In dichloromethane; water; for 0.166667h; Product distribution / selectivity;

upstream raw materials:

oxirane

3-bromo-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

4-(dimethylamino)-4-(3-methylphenyl)-spiro[cyclohexane-1,8'-(5,6,8,9-tetrahydropyrano[3,4-b]-7-azaindole)]

4-(methylamino)-4-phenyl-spiro[cyclohexane-1,8'-(5,6,8,9-tetrahydropyrano[3,4-b]-7-azaindole)]

4-(dimethylamino)-4-phenylethyl-spiro[cyclohexane-1,8'-(5,6,8,9-tetrahydropyrano[3,4-b]-7-azaindole)]

4-(dimethylamino)-4-(3-fluorophenyl)-spiro[cyclohexane-1,8'-(5,6,8,9-tetrahydropyrano[3,4-b]-7-azaindole)]