1,3,4-Thiadiazol-2-amine, 4-(4-fluorobenzoyl)-4,5-dihydro-N,5,5-trimethyl-N-[(methylamino)carbon yl]-

Base Information

• Chemical Name: 1,3,4-Thiadiazol-2-amine, 4-(4-fluorobenzoyl)-4,5-dihydro-N,5,5-trimethyl-N-[(methylamino)carbon yl]-
• CAS No.: 90929-87-6
• Molecular Formula: C₁₄H₁₇FN₄O₂S
• Molecular Weight: 324.379
• Mol file: 90929-87-6.mol

Synonyms:

Chemical Property of 1,3,4-Thiadiazol-2-amine, 4-(4-fluorobenzoyl)-4,5-dihydro-N,5,5-trimethyl-N-[(methylamino)carbon yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3,4-Thiadiazol-2-amine, 4-(4-fluorobenzoyl)-4,5-dihydro-N,5,5-trimethyl-N-[(methylamino)carbon yl]-

There total 2 articles about 1,3,4-Thiadiazol-2-amine, 4-(4-fluorobenzoyl)-4,5-dihydro-N,5,5-trimethyl-N-[(methylamino)carbon yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → 1-[4-(4-Fluoro-benzoyl)-5,5-dimethyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl]-1,3-dimethyl-urea (90929-87-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 74.1 percent / pyridine / 3 h / Ambient temperature

2: 1) triethylamine / 1) toluene, from -10 deg C to r.t., then 30 deg C, 2) toluene-water, 0-10 deg C, then r.t. 2 h

With pyridine; triethylamine;

Reference yield:

phosgene (75-44-5) + 4-(4-Fluorobenzoyl)-5,5-dimethyl-2-methylamino-4,5-dihydro-1,3,4-thiadiazole (83675-44-9) + methylamine (74-89-5) → 1-[4-(4-Fluoro-benzoyl)-5,5-dimethyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl]-1,3-dimethyl-urea (90929-87-6)

Guidance literature:

With triethylamine; Yield given. Multistep reaction; 1) toluene, from -10 deg C to r.t., then 30 deg C, 2) toluene-water, 0-10 deg C, then r.t. 2 h;

upstream raw materials:

phosgene

4-(4-Fluorobenzoyl)-5,5-dimethyl-2-methylamino-4,5-dihydro-1,3,4-thiadiazole

methylamine

4-fluorobenzoyl chloride

Refernces