Propanoic acid, 2-[2-methoxy-4-[(2S,3R,4R,5S)-tetrahydro-5-[3-methoxy-4-(phenylmeth oxy)phenyl]-3,4-dimethyl-2-furanyl]phenoxy]-, methyl ester, (2R)-

Base Information

Chemical Name:Propanoic acid, 2-[2-methoxy-4-[(2S,3R,4R,5S)-tetrahydro-5-[3-methoxy-4-(phenylmeth oxy)phenyl]-3,4-dimethyl-2-furanyl]phenoxy]-, methyl ester, (2R)-
CAS No.:915158-70-2
Molecular Formula:C31H36O7
Molecular Weight:520.623
Hs Code.:

Propanoic acid,
2-[2-methoxy-4-[(2S,3R,4R,5S)-tetrahydro-5-[3-methoxy-4-(phenylmeth
oxy)phenyl]-3,4-dimethyl-2-furanyl]phenoxy]-, methyl ester, (2R)-

Synonyms:

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Chemical Property of Propanoic acid, 2-[2-methoxy-4-[(2S,3R,4R,5S)-tetrahydro-5-[3-methoxy-4-(phenylmeth oxy)phenyl]-3,4-dimethyl-2-furanyl]phenoxy]-, methyl ester, (2R)-

Chemical Property:

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Technology Process of Propanoic acid, 2-[2-methoxy-4-[(2S,3R,4R,5S)-tetrahydro-5-[3-methoxy-4-(phenylmeth oxy)phenyl]-3,4-dimethyl-2-furanyl]phenoxy]-, methyl ester, (2R)-

There total 4 articles about Propanoic acid, 2-[2-methoxy-4-[(2S,3R,4R,5S)-tetrahydro-5-[3-methoxy-4-(phenylmeth oxy)phenyl]-3,4-dimethyl-2-furanyl]phenoxy]-, methyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 915158-67-7
4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenol

: 99208-98-7
methyl (S)-2-[(trifluoromethanesulfonyl)oxy]propionate

: 915158-70-2
(R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-propionic acid methyl ester

Guidance literature:: With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In dichloromethane; at -45 - 0 ℃;
DOI:10.1021/ol0621710

Reference yield:

: 915158-64-4
(1R,2R,3R,4S)-4-[4-(4-benzyloxy-3-methoxyphenyl)-1-hydroxy-4-methoxymethoxy-2,3-dimethylbutyl]-2-methoxyphenol

: 915158-70-2
(R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

2.1: MsCl; Et₃N / CH₂Cl₂ / -78 - 0 °C

2.2: 232 mg / LiOH; H₂O / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: 92 percent / BEMP / CH₂Cl₂ / -45 - 0 °C

With methanesulfonyl chloride; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; triethylamine; In dichloromethane;
DOI:10.1021/ol0621710

Reference yield:

: (1R,2R,3R)-1-(4-allyloxy-3-methoxyphenyl)-4-(4-benzyloxy-3-methoxyphenyl)-4-methoxymethoxy-2,3-dimethylbutan-1-ol

: 915158-70-2
(R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 0.86 g / Pd(PPh₃)4; NaBH₄ / tetrahydrofuran / 1 h / 20 °C

2.1: 94 percent / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

3.1: MsCl; Et₃N / CH₂Cl₂ / -78 - 0 °C

3.2: 232 mg / LiOH; H₂O / tetrahydrofuran; methanol / 2 h / 20 °C

4.1: 92 percent / BEMP / CH₂Cl₂ / -45 - 0 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonyl chloride; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol0621710