Propanamide, N-methoxy-2-[2-methoxy-4-[(2S,3R,4R,5S)-tetrahydro-5-[3-methoxy-4-( phenylmethoxy)phenyl]-3,4-dimethyl-2-furanyl]phenoxy]-N-methyl-, (2R)-

Base Information

Chemical Name:Propanamide, N-methoxy-2-[2-methoxy-4-[(2S,3R,4R,5S)-tetrahydro-5-[3-methoxy-4-( phenylmethoxy)phenyl]-3,4-dimethyl-2-furanyl]phenoxy]-N-methyl-, (2R)-
CAS No.:915158-80-4
Molecular Formula:C32H39NO7
Molecular Weight:549.664
Hs Code.:

Propanamide,
N-methoxy-2-[2-methoxy-4-[(2S,3R,4R,5S)-tetrahydro-5-[3-methoxy-4-(
phenylmethoxy)phenyl]-3,4-dimethyl-2-furanyl]phenoxy]-N-methyl-, (2R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanamide, N-methoxy-2-[2-methoxy-4-[(2S,3R,4R,5S)-tetrahydro-5-[3-methoxy-4-( phenylmethoxy)phenyl]-3,4-dimethyl-2-furanyl]phenoxy]-N-methyl-, (2R)-

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Technology Process of Propanamide, N-methoxy-2-[2-methoxy-4-[(2S,3R,4R,5S)-tetrahydro-5-[3-methoxy-4-( phenylmethoxy)phenyl]-3,4-dimethyl-2-furanyl]phenoxy]-N-methyl-, (2R)-

There total 5 articles about Propanamide, N-methoxy-2-[2-methoxy-4-[(2S,3R,4R,5S)-tetrahydro-5-[3-methoxy-4-( phenylmethoxy)phenyl]-3,4-dimethyl-2-furanyl]phenoxy]-N-methyl-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 915158-70-2
(R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-propionic acid methyl ester

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 915158-80-4
(R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-N-methoxy-N-methyl-propionamide

Guidance literature:: With dimethylaluminum chloride; In hexane; dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ol0621710

Reference yield:

: 915158-67-7
4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenol

: 915158-80-4
(R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-N-methoxy-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / BEMP / CH₂Cl₂ / -45 - 0 °C

2: 95 percent / Me₂AlCl / CH₂Cl₂; hexane / 1 h / 20 °C

With dimethylaluminum chloride; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In hexane; dichloromethane;
DOI:10.1021/ol0621710

Reference yield:

: 915158-64-4
(1R,2R,3R,4S)-4-[4-(4-benzyloxy-3-methoxyphenyl)-1-hydroxy-4-methoxymethoxy-2,3-dimethylbutyl]-2-methoxyphenol

: 915158-80-4
(R)-2-{4-[(2S,3R,4R,5S)-5-(4-Benzyloxy-3-methoxy-phenyl)-3,4-dimethyl-tetrahydro-furan-2-yl]-2-methoxy-phenoxy}-N-methoxy-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94 percent / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

2.1: MsCl; Et₃N / CH₂Cl₂ / -78 - 0 °C

2.2: 232 mg / LiOH; H₂O / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: 92 percent / BEMP / CH₂Cl₂ / -45 - 0 °C

4.1: 95 percent / Me₂AlCl / CH₂Cl₂; hexane / 1 h / 20 °C

With dimethylaluminum chloride; methanesulfonyl chloride; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; triethylamine; In hexane; dichloromethane;
DOI:10.1021/ol0621710