N-(2-Chlorophenyl)benzenesulfonamide

Base Information

• Chemical Name: N-(2-Chlorophenyl)benzenesulfonamide
• CAS No.: 21226-30-2
• Molecular Formula: C12H10 Cl N O2 S
• Molecular Weight: 267.736
• Hs Code.: 2935009090
• NSC Number: 673920,73196
• DSSTox Substance ID: DTXSID80291111
• Nikkaji Number: J1.426.615A
• Wikidata: Q82028957
• Mol file: 21226-30-2.mol

Synonyms:N-(2-Chlorophenyl)benzenesulfonamide;21226-30-2;NSC673920;2'-Chlorobenzenesulfonanilide;NSC73196;Cambridge id 5112585;NCIOpen2_003845;IFLab1_000467;SCHEMBL3791578;DTXSID80291111;KMSWCQQQRKBBAH-UHFFFAOYSA-N;HMS1413F05;MFCD00541867;NSC-73196;STL199640;AKOS000668869;CCG-105157;N-(2-Chlorophenyl)benzenesulfonamide #;NSC-673920;IDI1_008686;Benzenesulfonamide, N-(2-chlorophenyl)-;EU-0003045;N-(2-CHLOROPHENYL)-1-BENZENESULFONAMIDE

Chemical Property of N-(2-Chlorophenyl)benzenesulfonamide

Chemical Property:

• Vapor Pressure: 1.06E-06mmHg at 25°C
• Boiling Point: 402.9°Cat760mmHg
• Flash Point: 197.5°C
• PSA: 54.55000
• Density: 1.405g/cm³
• LogP: 4.29460
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 267.0120774
• Heavy Atom Count: 17
• Complexity: 333

Purity/Quality:

99%, ^*data from raw suppliers

N-(2-CHLOROPHENYL)BENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2Cl

Technology Process of N-(2-Chlorophenyl)benzenesulfonamide

There total 13 articles about N-(2-Chlorophenyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

triphenylbismuthane (603-33-8) + 2-Chloronitrobenzene (88-73-3) → 2-chloro-1-(benzenesulfonylamino)benzene (21226-30-2)

Guidance literature:

With sodium metabisulfite; copper(l) chloride; In melt; at 80 ℃; for 24h; chemoselective reaction; Green chemistry;

DOI:10.1039/c9gc01541h

Reference yield: 72.0%

benzenesulfonamide (98-10-2) + 2-chlorobenzenesulfinic acid sodium salt (15946-36-8) → 2-chloro-1-(benzenesulfonylamino)benzene (21226-30-2)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); silver(I) acetate; In 1,4-dioxane; dimethyl sulfoxide; at 120 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1080/00397911.2018.1452262

Reference yield: 60.0%

2-Chloronitrobenzene (88-73-3) + phenylboronic acid (98-80-6) → 2-chloro-1-(benzenesulfonylamino)benzene (21226-30-2)

Guidance literature:

With potassium pyrosulfite; tetrabutyl-ammonium chloride; potassium carbonate; In acetonitrile; at 130 ℃; for 24h; Sealed tube;

DOI:10.1021/acs.orglett.0c00183

upstream raw materials:

pyridine

N-chloro-N-phenylbenzenesulphonamide

N,N-dichloro-p-toluenesulfonamide

N-phenylbenzenesulfonamide

Downstream raw materials:

o-chloroaniline

benzene

[Benzenesulfonyl-(2-chloro-phenyl)-amino]-acetic acid

N-(4-fluorophenyl)benzenesulfonamide