L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-, 2-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-L-leucyl] hydrazide

Base Information

Chemical Name:L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-, 2-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-L-leucyl] hydrazide
CAS No.:93200-10-3
Molecular Formula:C₄₄H₆₆N₈O₁₀
Molecular Weight:867.056
Hs Code.:

L-Leucine,
N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-,
2-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-L-leucyl]
hydrazide

Synonyms:

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Chemical Property of L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-, 2-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-L-leucyl] hydrazide

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Technology Process of L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-, 2-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-L-leucyl] hydrazide

There total 9 articles about L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-, 2-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-L-leucyl] hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93199-90-7
(^tBOC-Gly-ΔPhe-(S)-Leu-NH-)2

: 93200-10-3,93302-22-8
({(R)-1-[(S)-1-(N'-{(S)-2-[(R)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamic acid tert-butyl ester

: 93302-22-8
({(S)-1-[(S)-1-(N'-{(S)-2-[(S)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; <((-)BPPM)Rh(norbornadiene)>(1+)*ClO4(1-); In ethanol; at 40 ℃; under 7600 Torr;
DOI:10.1016/S0040-4020(01)82412-1

Reference yield:

: 4530-20-5
BOC-glycine

: 93200-10-3,93302-22-8
({(R)-1-[(S)-1-(N'-{(S)-2-[(R)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1-hydroxybenzotriazole, N-methylmorpholine, N,N-dicyclohexylcarbodiimide / dimethylformamide

2: 1N NaOH / H₂O; methanol

3: NaOAc, Ac₂O

4: Et₃N / CHCl₃

5: 2N NaOH / H₂O; methanol / 5 °C

6: N-methylmorpholine / tetrahydrofuran / -15 °C

7: hydrazine hydrate

8: H₂ / <((-)BPPM)Rh(norbornadiene)⁽¹⁺⁾*ClO₄^(1-) / ethanol / 40 °C / 7600 Torr

With 4-methyl-morpholine; sodium hydroxide; hydrogen; sodium acetate; acetic anhydride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; <((-)BPPM)Rh(norbornadiene)>(1+)*ClO4(1-); In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)82412-1

Reference yield:

: 42267-16-3
(d,l)-phenylserine ethyl ester hydrochloride

: 93200-10-3,93302-22-8
({(R)-1-[(S)-1-(N'-{(S)-2-[(R)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1-hydroxybenzotriazole, N-methylmorpholine, N,N-dicyclohexylcarbodiimide / dimethylformamide

2: 1N NaOH / H₂O; methanol

3: NaOAc, Ac₂O

4: Et₃N / CHCl₃

5: 2N NaOH / H₂O; methanol / 5 °C

6: N-methylmorpholine / tetrahydrofuran / -15 °C

7: hydrazine hydrate

8: H₂ / <((-)BPPM)Rh(norbornadiene)⁽¹⁺⁾*ClO₄^(1-) / ethanol / 40 °C / 7600 Torr

With 4-methyl-morpholine; sodium hydroxide; hydrogen; sodium acetate; acetic anhydride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; <((-)BPPM)Rh(norbornadiene)>(1+)*ClO4(1-); In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)82412-1