2-([1,1'-Biphenyl]-4-yl)pyridine

Base Information

• Chemical Name: 2-([1,1'-Biphenyl]-4-yl)pyridine
• CAS No.: 93324-66-4
• Molecular Formula: C17H13N
• Molecular Weight: 231.297
• Nikkaji Number: J2.112.665I
• Mol file: 93324-66-4.mol

Synonyms:2-([1,1'-Biphenyl]-4-yl)pyridine;93324-66-4;2-(4-Biphenylyl)pyridine;2-(4-biphenylyl-)pyridin;2-(4-Biphenylyl)-pyridin;SCHEMBL750061;DB-163130

Chemical Property of 2-([1,1'-Biphenyl]-4-yl)pyridine

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 231.104799419
• Heavy Atom Count: 18
• Complexity: 236

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=CC=N3

Technology Process of 2-([1,1'-Biphenyl]-4-yl)pyridine

There total 20 articles about 2-([1,1'-Biphenyl]-4-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (874186-98-8) + 4-bromo-1,1'-biphenyl (92-66-0) → 2-(4-phenylphenyl)pyridine (93324-66-4)

Guidance literature:

With 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate; caesium carbonate; copper(l) chloride; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol802556f

Reference yield: 95.0%

2-(4-bromophenyl]pyridine (63996-36-1) + phenylboronic acid (98-80-6) → 2-(4-phenylphenyl)pyridine (93324-66-4)

Guidance literature:

With palladium diacetate; potassium carbonate; In ethanol; water; at 80 ℃;

Reference yield: 92.0%

2-bromo-pyridine (109-04-6) + 4-biphenylboronic acid (5122-94-1) → 2-(4-phenylphenyl)pyridine (93324-66-4)

Guidance literature:

With 1-(2,6-diisopropylphenyl)-3-(2-oxo-2-(2,4,6-tri-tert-butylphenylamino)ethyl)-1H-imidazol-3-ium bromide; palladium diacetate; potassium carbonate; In dichloromethane; toluene; at 100 ℃; for 5h; Reflux;

DOI:10.1002/adsc.201000592

upstream raw materials:

benzene

pyridin-2-yl trifluoromethanesulfonate

4-bromo-1,1'-biphenyl

2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Downstream raw materials:

2-([1,1'-biphenyl]-4-yl)-6-phenylpyridine

4-(pyridin-2-yl)-(1,1'-biphenyl)-3-carbonitrile

phenyl(4-(pyridin-2-yl)-[1,1'-biphenyl]-3-yl)methanone

4-(pyridin-2-yl)-[1,1’-biphenyl]-3-ol