1-Benzyl-4-phenyl-4-(propionyloxy)piperidine

Base Information

• Chemical Name: 1-Benzyl-4-phenyl-4-(propionyloxy)piperidine
• CAS No.: 94909-63-4
• Molecular Formula: C₂₁H₂₅NO₂
• Molecular Weight: 323.435
• DSSTox Substance ID: DTXSID101345670
• Nikkaji Number: J1.826.395E
• Mol file: 94909-63-4.mol

Synonyms:SCHEMBL19717856;DTXSID101345670;1-Benzyl-4-phenylpiperidin-4-yl propanoate;1-Benzyl-4-phenyl-4-(propionyloxy)piperidine;94909-63-4

Chemical Property of 1-Benzyl-4-phenyl-4-(propionyloxy)piperidine

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 323.188529040
• Heavy Atom Count: 24
• Complexity: 389

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC(=O)OC1(CCN(CC1)CC2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-Benzyl-4-phenyl-4-(propionyloxy)piperidine

There total 4 articles about 1-Benzyl-4-phenyl-4-(propionyloxy)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-4-hydroxy-4-phenylpiperidine (63843-83-4) + propionic acid anhydride (123-62-6) → propionic acid-(1-benzyl-4-phenyl-[4]piperidyl ester) (94909-63-4)

Guidance literature:

With sulfuric acid;

DOI:10.1021/ja01551a038 DOI:10.1021/jo01170a022

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → propionic acid-(1-benzyl-4-phenyl-[4]piperidyl ester) (94909-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: sulfuric acid

With diethyl ether; sulfuric acid;

DOI:10.1021/jo01170a022

Reference yield:

phenyllithium (591-51-5) → propionic acid-(1-benzyl-4-phenyl-[4]piperidyl ester) (94909-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: sulfuric acid

With diethyl ether; sulfuric acid;

DOI:10.1021/jo01170a022

upstream raw materials:

1-benzyl-4-hydroxy-4-phenylpiperidine

propionic acid anhydride

3-benzyl-6-methyl-6-phenyl-[1,3]oxazinane

1-phenylmethyl-4-piperidone