Imidazo(2,1-b)thiazol-5(6H)-one, 2,3-dihydro-6-((4-chlorophenyl)methylene)-

Base Information

Chemical Name:Imidazo(2,1-b)thiazol-5(6H)-one, 2,3-dihydro-6-((4-chlorophenyl)methylene)-
CAS No.:129228-63-3
Molecular Formula:C₁₂H₉ClN₂OS
Molecular Weight:264.735
Hs Code.:
DSSTox Substance ID:DTXSID50156122
Mol file:129228-63-3.mol

Synonyms:129228-63-3;Imidazo(2,1-b)thiazol-5(6H)-one, 2,3-dihydro-6-((4-chlorophenyl)methylene)-;2,3-Dihydro-6-(4-chlorobenzylidene)imidazo(2,1-b)thiazol-5(6H)-one;(6E)-6-[(4-chlorophenyl)methylidene]-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-one;(6E)-6-(4-Chlorobenzylidene)-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5(6H)-one;Imidazo(2,1-b)thiazol-5(6H)-one, 2,3-dihydro-6-((4-chlorophenyl)methyl ene)-;DTXSID50156122;OMWVQYRUAQMEGW-JXMROGBWSA-N;LS-80685

Suppliers and Price of Imidazo(2,1-b)thiazol-5(6H)-one, 2,3-dihydro-6-((4-chlorophenyl)methylene)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Imidazo(2,1-b)thiazol-5(6H)-one, 2,3-dihydro-6-((4-chlorophenyl)methylene)-

Chemical Property:

Vapor Pressure:3.54E-07mmHg at 25°C
Melting Point:>300 °C(Solv: ethanol (64-17-5))
Boiling Point:417.5°Cat760mmHg
PKA:-1.44±0.20(Predicted)
Flash Point:206.3°C
PSA：57.97000
Density:1.49g/cm³
LogP:1.99940
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:264.0124118
Heavy Atom Count:17
Complexity:399

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CSC2=NC(=CC3=CC=C(C=C3)Cl)C(=O)N21
Isomeric SMILES:C1CSC2=N/C(=C/C3=CC=C(C=C3)Cl)/C(=O)N21

Technology Process of Imidazo(2,1-b)thiazol-5(6H)-one, 2,3-dihydro-6-((4-chlorophenyl)methylene)-

There total 3 articles about Imidazo(2,1-b)thiazol-5(6H)-one, 2,3-dihydro-6-((4-chlorophenyl)methylene)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2-(2-Bromo-ethylsulfanyl)-5-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-3,5-dihydro-imidazol-4-one

: 129228-63-3
6-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-2,3-dihydro-6H-imidazo[2,1-b]thiazol-5-one

Guidance literature:: With PPA; at 100 - 130 ℃; for 1.5h;
DOI:10.1080/104265090968677

Reference yield: 48.0%

: 280137-25-9
2-thioxo-5-(4-chlorophenylmethylidene)-4-imidazolidinone

: 106-93-4
ethylene dibromide

: 2,3-dihydro-5-(4-chlorobenzylidene)-imidazo-<2,1-b>-thiazol-6(5H)-one

: 129228-63-3
Z-6-(4-Chlorobenzylidene)-2,3-dihydroimidazo-<2,1-b>-thiazol-5(6H)-one

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In acetone; for 48h; Ambient temperature;

Reference yield:

: 37428-88-9
5-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-2-thioxo-imidazolidin-4-one

: 129228-63-3
6-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-2,3-dihydro-6H-imidazo[2,1-b]thiazol-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / sodium ethoxide / ethanol / 5 h

2: 70 percent / polyphosphoric acid / 1.5 h / 100 - 130 °C

With PPA; sodium ethanolate; In ethanol;
DOI:10.1080/104265090968677