Phosphorochloridic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Base Information

Chemical Name:Phosphorochloridic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester
CAS No.:103309-63-3
Molecular Formula:C₃₇H₃₅Cl₂N₂O₉P
Molecular Weight:753.573
Hs Code.:

Phosphorochloridic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Synonyms:Phosphorochloridic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

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Chemical Property of Phosphorochloridic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

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Technology Process of Phosphorochloridic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

There total 1 articles about Phosphorochloridic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 15074-54-1
2-chlorophenyl dichlorophosphate

: 103309-63-3
Phosphorochloridic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Guidance literature:: With 1,2,4-Triazole; 1-methyl-1H-imidazole; triethylamine; In tetrahydrofuran; for 0.166667h;
DOI:10.1080/07328319908044627

Reference yield:

: 121-44-8
triethylamine

: 103309-63-3
Phosphorochloridic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

: 85393-37-9
5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

Guidance literature:: With water; In tetrahydrofuran;
DOI:10.1080/07328319908044627

Reference yield:

: 103309-63-3
Phosphorochloridic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

: Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester hexadecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂O / tetrahydrofuran

2: 100 percent / MSNT / pyridine / 0.5 h / 20 °C

3: syn-2-nitrobenzaldoxime; 1,1,3,3-tetramethylguanidine; H₂O / dioxane / 3 h / 20 °C

With MSNT; (Z)-2-nitrobenzaldehyde oxime; water; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; 1,4-dioxane; pyridine; 1: Hydrolysis / 2: Condensation / 3: Hydrolysis;
DOI:10.1080/07328319908044627