5-amino-1,2-dihydropyrazol-3-one

Base Information

• Chemical Name: 5-amino-1,2-dihydropyrazol-3-one
• CAS No.: 28491-52-3
• Molecular Formula: C3H5N3O
• Molecular Weight: 99.0922
• Hs Code.: 2933199090
• Mol file: 28491-52-3.mol

Synonyms:3-Pyrazolin-5-one,3-amino- (6CI,7CI);Pyrazol-3-ol, 5-amino- (8CI);3-Amino-1H-pyrazol-5-ol;3-Amino-3-pyrazolin-5-one;5-Amino-1,2-dihydro-3H-pyrazol-3-one;5-Amino-1H-pyrazol-3-ol;5-Amino-2,3-dihydro-1H-pyrazol-3-one;5-Amino-3-hydroxy-1H-pyrazole;5-Amino-3-pyrazolone;5-Aminopyrazol-3-ol;NSC 408479;NSC 60188;

Chemical Property of 5-amino-1,2-dihydropyrazol-3-one

Chemical Property:

• Melting Point: 204℃
• Boiling Point: 479.5 °C at 760 mmHg
• PKA: 8.31±0.70(Predicted)
• Flash Point: 243.8 °C
• PSA: 74.67000
• Density: 1.301 g/cm³
• LogP: -0.13360
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Amino-1H-pyrazol-3(2H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-amino-1,2-dihydropyrazol-3-one

There total 6 articles about 5-amino-1,2-dihydropyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylic acid (37832-55-6) → 5-amino-1,2-dihydropyrazol-3-one (28491-52-3)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In toluene; at 80 ℃; for 5h; Temperature; Solvent;

Reference yield:

ethyl 3-amino-3-ethoxypropenoate (39632-87-6) → 5-amino-1,2-dihydropyrazol-3-one (28491-52-3)

Guidance literature:

With ethanol; hydrazine hydrate;

Reference yield:

Cyanoacetohydrazide (140-87-4) + sodium methylate (124-41-4) → 5-amino-1,2-dihydropyrazol-3-one (28491-52-3)

Guidance literature:

With methanol;

upstream raw materials:

Cyanoacetohydrazide

sodium methylate

sodium ethanolate

ethyl 3-amino-3-ethoxypropenoate

Downstream raw materials:

5-amino-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid ethyl ester

4-phenethylidene-5-phenethylidenamino-2,4-dihydro-pyrazol-3-one

6-hydroxy-4-methyl-3-oxo-2,3-dihydro-pyrazolo<3,4-b>pyridine

7-hydroxy-5-methyl-2-oxo-1,2-dihydro-pyrazolo<1,5-a>pyrimidine

Refernces