(+)-Cisapride

Base Information

Chemical Name:(+)-Cisapride
CAS No.:86718-70-9
Molecular Formula:C₂₃H₂₉ClFN₃O₄
Molecular Weight:465.952
Hs Code.:
Mol file:86718-70-9.mol

Synonyms:(+)-cis-Apride;(+)-(R)-Cisapride;

Suppliers and Price of (+)-Cisapride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(+)-(R)-CISAPRIDE 95.00%
10MG
$ 217.35

Total 4 raw suppliers

Chemical Property of (+)-Cisapride

Chemical Property:

PSA：89.54000
LogP:4.45200

Purity/Quality:: (+)-(R)-CISAPRIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (+)-Cisapride

There total 12 articles about (+)-Cisapride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 503433-37-2
C₁₅H₂₃FN₂O₂

: 150007-96-8
C₁₁H₁₂ClNO₅

: 81098-60-4,86718-68-5,86719-31-5,86719-33-7,104860-66-4,104860-73-3,86718-70-9
(+)-(3S,4R)-cisapride

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 16h;
DOI:10.1016/j.tet.2011.12.084

Reference yield:

: 7206-70-4
4-amino-5-chloro-2-methoxybenzoic acid

: 503433-37-2
C₁₅H₂₃FN₂O₂

: 81098-60-4,86718-68-5,86719-31-5,86719-33-7,104860-66-4,104860-73-3,86718-70-9
(+)-(3S,4R)-cisapride

Guidance literature:: 4-amino-5-chloro-2-methoxybenzoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran;

C₁₅H₂₃FN₂O₂; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/j.tetasy.2011.08.020

Reference yield:

: 1345718-94-6
tert-butyl (E)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate

: 81098-60-4,86718-68-5,86719-31-5,86719-33-7,104860-66-4,104860-73-3,86718-70-9
(+)-(3S,4R)-cisapride

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 2 h / -78 °C

1.2: 12 h / -78 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane / 3 h / 35 °C

3.1: benzoic acid / toluene / 16 h / 80 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

4.2: 16 h / 0 - 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 60 °C

6.1: 20 % Pd(OH)2/C; hydrogen / methanol / 16 h / 20 °C

7.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran

7.2: 16 h / 20 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; 20 % Pd(OH)2/C; hydrogen; chloroformic acid ethyl ester; sodium hydride; triethylamine; benzoic acid; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/j.tetasy.2011.08.020