3-Methoxyoxetane

Base Information

• Chemical Name: 3-Methoxyoxetane
• CAS No.: 1872-45-3
• Molecular Formula: C₄H₈O₂
• Molecular Weight: 88.1063
• Hs Code.: 2932990090
• Mol file: 1872-45-3.mol

Synonyms:3-methoxyoxetane

Chemical Property of 3-Methoxyoxetane

Chemical Property:

• Boiling Point: 98.357 °C at 760 mmHg
• Flash Point: 15.303 °C
• PSA: 18.46000
• Density: 0.992 g/cm³
• LogP: 0.03160

Purity/Quality:

99% ^*data from raw suppliers

3-METHOXYOXETANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• General Description: 3-Methoxyoxetane is synthesized through the conjugate addition of methoxide anion to 3-(phenylseleno)-2-propenal, followed by ring closure via selenium elimination, demonstrating its utility as a product in oxetane ring formation and three-carbon unit incorporation into nucleophiles. This method highlights its relevance in organic synthesis for constructing functionalized oxetane derivatives.

Technology Process of 3-Methoxyoxetane

There total 1 articles about 3-Methoxyoxetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-Methoxyoxetan (1872-45-3)

Guidance literature:

Methanol, Allylalkohol, Chlor;

DOI:10.1021/jo00815a007

Reference yield:

methanol (67-56-1) + 3-Methoxyoxetan (1872-45-3) → 2,3-dimethoxypropan-1-ol (40453-77-8)

Guidance literature:

With sulfuric acid;

Reference yield:

3-Methoxyoxetan (1872-45-3) + phenol (108-95-2,27073-41-2) → 3-Phenoxy-2-methoxy-propan-1-ol (40453-79-0)

Guidance literature:

With sodium hydroxide;

Downstream raw materials:

2,3-dimethoxypropan-1-ol

3-Phenoxy-2-methoxy-propan-1-ol

Refernces

Flash Vacuum Pyrolysis of N-Allyl-Substituted 1,3,4-Oxadiazolin-5-ones

10.1021/jo01308a031

The research focuses on two main chemical processes. The first process investigates the formation of oxetane rings and the introduction of a three-carbon unit into various nucleophiles using 3-(phenylseleno)-2-propenal as an efficient reagent. This method involves a conjugate addition of methoxide anion followed by ring closure through elimination of the selenium moiety, yielding products such as 3-methoxyoxetanes. The second process explores the flash vacuum pyrolysis of N-allyl-substituted 1,3,4-oxadiazolin-5-ones, which generates nitrile imines that rearrange to diazoalkenes via a 3,3-sigmatropic shift. This research provides valuable insights into the rearrangement mechanisms and offers a new route to homologated derivatives, with potential applications in organic synthesis. The chemicals used in these processes include 3-(phenylseleno)-2-propenal, MCPBA (m-chloroperbenzoic acid), sodium hydroxide, methanol, and a variety of N-allyl-substituted 1,3,4-oxadiazolin-5-ones, among others. The conclusions drawn from these studies highlight the efficiency and potential applications of the described methods in synthesizing complex organic compounds.

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