2,3-dimethoxypropan-1-ol

Base Information

• Chemical Name: 2,3-dimethoxypropan-1-ol
• CAS No.: 40453-77-8
• Molecular Formula: C5H12O3
• Molecular Weight: 120.148
• Mol file: 40453-77-8.mol

Synonyms:1-Propanol,2,3-dimethoxy;2,3-(OMe)2-1-propanol;2.3-dimethoxy-1-propanol;2,3-dimethoxy-propan-1-ol;1,2-dimethyl glycerol ether;(rac)-2,3-dimethoxypropanol;2,3-dimethoxypropanol;

Chemical Property of 2,3-dimethoxypropan-1-ol

Chemical Property:

• Vapor Pressure: 0.271mmHg at 25°C
• Boiling Point: 179.999°C at 760 mmHg
• PKA: 14.20±0.10(Predicted)
• Flash Point: 62.802°C
• PSA: 38.69000
• Density: 0.987g/cm³
• LogP: -0.35990

Purity/Quality:

99% ^*data from raw suppliers

2,3-dimethoxypropan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-dimethoxypropan-1-ol

There total 17 articles about 2,3-dimethoxypropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2,3-di-O-methyl-DL-glyceraldehyde (105444-34-6) → 2,3-dimethoxypropan-1-ol (40453-77-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 0.0833333h;

Reference yield: 78.0%

1-benzyloxy-2,3-dimethoxypropane (28959-03-7,148823-50-1) → 2,3-dimethoxypropan-1-ol (40453-77-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 30 ℃; for 48h;

Reference yield:

methanol (67-56-1) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → glycerol 1-monomethyl ether (623-39-2,36887-04-4) + 2,3-dimethoxypropan-1-ol (40453-77-8) + 1,3-dimethyl glycerol ether (623-69-8)

Guidance literature:

With trifluorormethanesulfonic acid; (acetonitrile)(2,2'-bipyridine)(η5-cyclopentadienyl)ruthenium(II) triflate; hydrogen; In sulfolane; at 200 ℃; for 3.5h; under 25877.6 Torr; Autoclave;

DOI:10.1039/c0gc00255k

upstream raw materials:

2,3-Dibromopropan-1-ol

sodium methylate

1-Chlor-2,3-dimethoxy-propane

glycerol

Downstream raw materials:

2-oxopropanal

Refernces

• 1、 Sutter, Marc,Dayoub, Wissam,Metay, Estelle,Raoul, Yann,Lemaire, Marc. "1,2,3-Trimethoxypropane and glycerol ethers as bio-sourced solvents from glycerol: Synthesis by solvent-free phase-transfer catalysis and utilization as an alternative solvent in chemical transformations". . p. 2893 - 2904. Retrieved 2013/10/21.
• 2、 Thibault, Michelle E.,Dimondo, Domenico V.,Jennings, Michael,Abdelnur, Patricia Verardi,Eberlin, Marcos N.,Schlaf, Marcel. "Cyclopentadienyl and pentamethylcyclopentadienyl ruthenium complexes as catalysts for the total deoxygenation of 1,2-hexanediol and glycerol". experimental part. p. 357 - 366. Retrieved 2011/04/18.