1-(6-chloroH-iMidazo[1,2-a]pyridin-3-yl)ethanone

Base Information

• Chemical Name: 1-(6-chloroH-iMidazo[1,2-a]pyridin-3-yl)ethanone
• CAS No.: 30493-40-4
• Molecular Formula: C₉H₇ClN₂O
• Molecular Weight: 194.62
• Hs Code.: 2934999090
• Mol file: 30493-40-4.mol

Synonyms:1-(6-chloroimidazo[1,2-a]pyridin-3-yl)ethanone;1-(6-chloroH-iMidazo[1,2-a]pyridin-3-yl)ethanone;1-{6-chloroimidazo[1,2-a]pyridin-3-yl}ethan-1-one;Ethanone, 1-(6-chloroiMidazo[1,2-a]pyridin-3-yl)-

Chemical Property of 1-(6-chloroH-iMidazo[1,2-a]pyridin-3-yl)ethanone

Chemical Property:

• PSA: 44.12000
• LogP: 1.55830

Purity/Quality:

98% ^*data from raw suppliers

1-(6-Chloro-imidazo[1,2-a]pyridin-3-yl)-ethanone 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(6-chloroH-iMidazo[1,2-a]pyridin-3-yl)ethanone

There total 2 articles about 1-(6-chloroH-iMidazo[1,2-a]pyridin-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

5-chloro-2-pyridylamine (1072-98-6) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + 1-bromoacetone (598-31-2) → 1-(6-chloroimidazo[1,2-a]pyridin-3-yl)ethan-1-one (30493-40-4)

Guidance literature:

5-chloro-2-pyridylamine; N,N-dimethyl-formamide dimethyl acetal; for 23h; Heating;

1-bromoacetone; In ethanol; at 20 ℃; for 18h; Further stages.;

DOI:10.1016/j.bmc.2006.09.047

Reference yield: 10.0%

→ 1-(6-chloroimidazo[1,2-a]pyridin-3-yl)ethan-1-one (30493-40-4)

Guidance literature:

In N,N-dimethyl-formamide; for 23h; Reflux;

In ethanol; N,N-dimethyl-formamide;

Reference yield:

1-(6-chloroimidazo[1,2-a]pyridin-3-yl)ethan-1-one (30493-40-4) → 6-chloro-3-{2-[(2-methyl-5-nitrophenyl)thio]-1,3-thiazol-4-yl}imidazo[1,2-a]pyridine (372198-16-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 90 percent / Br₂; aq. HBr; AcOH / 32 h / 20 °C

2.1: methanol / 0.25 h / 20 °C

2.2: 71 percent / AcOH / 1 h / Heating

3.1: NaNO₂; aq. HCl; NaBF₄ / H₂O / 0.5 h / 20 °C

3.2: 19 percent / NaH / dimethylsulfoxide / 0.17 h / 20 °C

With hydrogenchloride; sodium tetrafluoroborate; hydrogen bromide; bromine; acetic acid; sodium nitrite; In methanol; water;

DOI:10.1016/j.bmc.2006.09.047

upstream raw materials:

5-chloro-2-pyridylamine

N,N-dimethyl-formamide dimethyl acetal

1-bromoacetone

Downstream raw materials:

6-chloro-3-{2-[(2-methyl-5-nitrophenyl)thio]-1,3-thiazol-4-yl}imidazo[1,2-a]pyridine

ethyl 2-{[4-(6-chloroimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-yl]thio}-4-nitrobenzoate

(2-{[4-(6-chloroimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-yl]thio}-4-nitrophenyl)methanol

(2-{[4-(6-chloroimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-yl]sulfinyl}-4-nitrophenyl)methanol

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