ethyl 2-{[4-(6-chloroimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-yl]thio}-4-nitrobenzoate

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Chemical Name:ethyl 2-{[4-(6-chloroimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-yl]thio}-4-nitrobenzoate
CAS No.:917926-26-2
Molecular Formula:C₁₉H₁₃ClN₄O₄S₂
Molecular Weight:460.922
Hs Code.:

Synonyms:ethyl 2-{[4-(6-chloroimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-yl]thio}-4-nitrobenzoate

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Chemical Property of ethyl 2-{[4-(6-chloroimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-yl]thio}-4-nitrobenzoate

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Technology Process of ethyl 2-{[4-(6-chloroimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-yl]thio}-4-nitrobenzoate

There total 4 articles about ethyl 2-{[4-(6-chloroimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-yl]thio}-4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 372198-66-8
4-(6-chloroimidazo[1,2-a]pyridin-3-yl)-1,3-thiazole-2-thiol

: 914347-91-4
ethyl 2-fluoro-4-nitrobenzoate

: 917926-26-2
ethyl 2-{[4-(6-chloroimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-yl]thio}-4-nitrobenzoate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 90 ℃; for 7h;
DOI:10.1016/j.bmc.2006.09.047

Reference yield:

: 1072-98-6
5-chloro-2-pyridylamine

: 917926-26-2
ethyl 2-{[4-(6-chloroimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-yl]thio}-4-nitrobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 23 h / Heating

1.2: 25 percent / ethanol / 18 h / 20 °C

2.1: 90 percent / Br₂; aq. HBr; AcOH / 32 h / 20 °C

3.1: methanol / 0.25 h / 20 °C

3.2: 71 percent / AcOH / 1 h / Heating

4.1: 25 percent / NaH / dimethylformamide / 7 h / 90 °C

With hydrogen bromide; bromine; sodium hydride; acetic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.09.047

Reference yield:

: 30493-40-4
1-(6-chloroimidazo[1,2-a]pyridin-3-yl)ethan-1-one

: 917926-26-2
ethyl 2-{[4-(6-chloroimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-yl]thio}-4-nitrobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / Br₂; aq. HBr; AcOH / 32 h / 20 °C

2.1: methanol / 0.25 h / 20 °C

2.2: 71 percent / AcOH / 1 h / Heating

3.1: 25 percent / NaH / dimethylformamide / 7 h / 90 °C

With hydrogen bromide; bromine; sodium hydride; acetic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.09.047