8-CHLOROQUINAZOLIN-4(1H)-ONE

Base Information

• Chemical Name: 8-CHLOROQUINAZOLIN-4(1H)-ONE
• CAS No.: 101494-95-5
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.59
• Hs Code.: 2933998090
• Mol file: 101494-95-5.mol

Synonyms:8-CHLOROQUINAZOLIN-4(1H)-ONE;8-chloroquinazolin-4(3H)-one;8-chloroquinazolin-4-ol

Chemical Property of 8-CHLOROQUINAZOLIN-4(1H)-ONE

Chemical Property:

• Melting Point: 302℃
• PSA: 46.01000
• Density: 1.50±0.1 g/cm3 (20 ºC 760 Torr)
• LogP: 1.98880
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

8-Chloroquinazolin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-CHLOROQUINAZOLIN-4(1H)-ONE

There total 6 articles about 8-CHLOROQUINAZOLIN-4(1H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-amino-3-chlorobenzoic acid (6388-47-2) + formamide (77287-34-4,77287-35-5,60100-09-6) → 8-chloroquinazolin-4(3H)-one (101494-95-5)

Guidance literature:

at 140 ℃;

DOI:10.1016/j.ejmech.2012.02.001

Reference yield: 68.0%

methanol (67-56-1) + 2-amino-3-chloro-benzamide (18343-44-7) → 8-chloroquinazolin-4(3H)-one (101494-95-5)

Guidance literature:

With [Cp*Ir(2,2′-bpyO)(H₂O)]; caesium carbonate; at 130 ℃; for 2h; Microwave irradiation; Green chemistry;

DOI:10.1021/acs.orglett.6b00925

Reference yield:

7-chloroisatin (7477-63-6) → 8-chloroquinazolin-4(3H)-one (101494-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous NaOH; aqueous H₂O₂

2: 175 °C

With sodium hydroxide; dihydrogen peroxide;

DOI:10.1021/jo01135a015

upstream raw materials:

4-Hydroxyquinazoline

2-amino-3-chlorobenzoic acid

formamide

chlorine

Downstream raw materials:

4,8-dichloroquinazoline

2-{2-[6-(8-chloro-4-oxo-4H-quinazolin-3-yl)-pyrimidin-4-yloxy]phenyl}-3-methoxy-acrylic acid methyl ester