6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE

Base Information

• Chemical Name: 6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE
• CAS No.: 135481-57-1
• Molecular Formula: C14H15N3O2
• Molecular Weight: 257.292
• Hs Code.: 2933990090
• Mol file: 135481-57-1.mol

Synonyms:6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE;6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione;6-benzyl-1H,2H,3H,4H,5H,6H,7H,8H-pyrido[4,3-d]pyriMidine-2,4-dione;6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidin-2,4(1H,3H)-dione;6-Benzyl-5,6,7,8-tetrahyd...;5,6,7,8-Tetrahydro-6-(phenylmethyl)pyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione;NSC 525977

Chemical Property of 6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE

Chemical Property:

• PKA: 10.04±0.20(Predicted)
• PSA: 68.96000
• Density: 1.33
• LogP: 0.55940
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE

There total 12 articles about 6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-ethoxy-5,6,7,8-tetrahydro-6-(phenylmethyl)-pyrido<4,3-d>pyrimidin-2(1H)-one (135481-54-8) → 5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido<3,4-d>pyrimidine-2,4(1H,3H)-dione (135481-57-1)

Guidance literature:

With hydrogenchloride; for 4h; Heating;

DOI:10.1021/jm00113a032

Reference yield: 75.0%

C9H14O3NC6H5 (41276-30-6) + urea (57-13-6) → 5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido<3,4-d>pyrimidine-2,4(1H,3H)-dione (135481-57-1)

Guidance literature:

With sodium methylate; In ethanol; for 24h; Reflux;

DOI:10.1016/j.ejmech.2014.03.061

Reference yield: 70.0%

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) + urea (57-13-6) → 5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido<3,4-d>pyrimidine-2,4(1H,3H)-dione (135481-57-1)

Guidance literature:

With sodium methylate; In ethanol; for 24h; Heating / reflux;

upstream raw materials:

4-ethoxy-5,6,7,8-tetrahydro-6-(phenylmethyl)-pyrido<4,3-d>pyrimidin-2(1H)-one

urea

1-benzyl-4-aminotetrahydropyridine-3-carboxylic acid methyl ester

6-benzyl-2-thioxo-2,3,5,6,7,8-hexahydro-1H-pyrido<4,3-d>pyrimidin-4-one

Downstream raw materials:

6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine

6-Benzyl-2,4-dibromo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

C₂₅H₃₄N₆O₄

C₂₄H₂₈N₈O₂