[R-(R,S)]-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid ethyl ester

Base Information

Chemical Name:[R-(R*,S*)]-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid ethyl ester
CAS No.:172336-33-3
Molecular Formula:C27H28FNO4
Molecular Weight:449.51400
Hs Code.:
Mol file:172336-33-3.mol

Synonyms:Ethyl [R-(R*,S*)]-3,5-dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-hept-6-enoate;[R-(R*,S*)]-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid ethyl ester;6-Heptenoic acid,7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-,ethyl ester,[3R,5(R*,S*)]-

Suppliers and Price of [R-(R*,S*)]-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 15 raw suppliers

Chemical Property of [R-(R*,S*)]-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid ethyl ester

Chemical Property:

PSA：79.65000
Density:1.271
LogP:4.99660

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [R-(R*,S*)]-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid ethyl ester

There total 72 articles about [R-(R*,S*)]-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 254452-91-0
ethyl 5(S)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate

: 167073-19-0,172336-32-2,172336-33-3
(E)-(3R,5S)-7-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid ethyl ester

Guidance literature:: With methanol; sodium tetrahydroborate; diethyl methoxy borane; In tetrahydrofuran; ethyl acetate; at -80 - -75 ℃; for 5h; Product distribution / selectivity; Inert atmosphere;

Reference yield: 58.5%

: 148901-69-3
(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxohept-6-enic acid ethyl ester

: 172336-32-2,172336-33-3
(±)-E-3,5-dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-6-heptenoic acid ethyl ester

Guidance literature:: (E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxohept-6-enic acid ethyl ester; With diethyl methoxy borane; In tetrahydrofuran; methanol; at -75 ℃; for 1h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -75 ℃; for 3h;
DOI:10.1016/S0968-0896(01)00198-5

Reference yield:

: 166803-31-2
(E)-7-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dioxo-hept-6-enoic acid ethyl ester

: 172336-32-2,172336-33-3
(E)-(3R,5S)-7-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid ethyl ester

Guidance literature:: With formic acid; (1R,2R)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine-RuII-p-cymene; triethylamine; In N,N-dimethyl acetamide; at 50 ℃; for 19.6667h;