ethyl 5(R)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate

Base Information

Chemical Name:ethyl 5(R)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate
CAS No.:254452-95-4
Molecular Formula:C₂₇H₂₆FNO₄
Molecular Weight:447.506
Hs Code.:

Synonyms:

Suppliers and Price of ethyl 5(R)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 5(R)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ethyl 5(R)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate

There total 8 articles about ethyl 5(R)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 674-82-8,2130-41-8
4-methyleneoxetan-2-one

: 3087-36-3
titanium (IV) ethoxide

: 148901-68-2,121660-63-7
(E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-propenal

: 254452-95-4
ethyl 5(R)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate

: 254452-91-0
ethyl 5(S)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: 4-methyleneoxetan-2-one; titanium (IV) ethoxide; (E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-propenal; With titanium(IV) isopropylate; (S)-2-(N-3-tert-butylsalicylidene)amino-3-methyl-1-butanol; In dichloromethane; at -50 ℃; for 62h;

With oxalic acid; In dichloromethane; at 20 ℃; for 2h; Title compound not separated from byproducts;
DOI:10.1560/PX53-Y9JJ-FU8V-GKEN

Reference yield:

: 121660-11-5
2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline

: 254452-95-4
ethyl 5(R)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: Multi-step reaction with 6 steps

1: DMSO; P₂O₅; Et₃N

2: NaOH; (n-octyl)3MeNCl / toluene; H₂O

3: DIBAH

4: LDA; MgBr₂

6: LDA

With sodium hydroxide; phosphorus pentoxide; Aliquat 336; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; magnesium bromide; lithium diisopropyl amide; In water; toluene; 1: Oxidation / 2: Condensation / 3: Reduction / 4: Addition / 5: Methylation / 6: Claisen condensation;
DOI:10.1016/S0960-894X(99)00519-3

Reference yield:

: 148901-68-2,121660-63-7
(E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-propenal

: 254452-95-4
ethyl 5(R)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: Multi-step reaction with 3 steps

1: LDA; MgBr₂

3: LDA

With magnesium bromide; lithium diisopropyl amide; 1: Addition / 2: Methylation / 3: Claisen condensation;
DOI:10.1016/S0960-894X(99)00519-3