4-Fluoro-trans-beta-styrylboro

Base Information

• Chemical Name: 4-Fluoro-trans-beta-styrylboro
• CAS No.: 504433-86-7
• Molecular Formula: C14H18BFO2
• Molecular Weight: 248.105
• Hs Code.: 2934999090
• Mol file: 504433-86-7.mol

Synonyms:(E)-2-(4-fluorostyryl)boronic acid pinacol ester;(E)-2-(4-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;4FC6H4CH=CH(Bpin);

Chemical Property of 4-Fluoro-trans-beta-styrylboro

Chemical Property:

• PSA: 18.46000
• LogP: 3.47030
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(E)-2-(4-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoro-trans-beta-styrylboro

There total 25 articles about 4-Fluoro-trans-beta-styrylboro which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-ethynyl-4-fluorobenzene (766-98-3) + bis(pinacol)diborane (73183-34-3) → 2-[(1E)-2-(4-fluorophenyl)ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (504433-86-7)

Guidance literature:

With 2.9 weight% Cu(II) loaded porous coordination network-222 nanoparticles; In ethanol; water; at 80 ℃; regioselective reaction; Sealed tube;

DOI:10.1016/j.jcat.2021.06.013

Reference yield: 97.0%

1-ethynyl-4-fluorobenzene (766-98-3) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 2-[(1E)-2-(4-fluorophenyl)ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (504433-86-7)

Guidance literature:

With lithium hexamethyldisilazane; In toluene; at 80 ℃; for 24h; Inert atmosphere;

Reference yield: 95.0%

para-fluorostyrene (405-99-2) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 2-[(1E)-2-(4-fluorophenyl)ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (504433-86-7)

Guidance literature:

With bis(cyclopentadienyl)dihydrozirconium; In toluene; at 25 ℃; Inert atmosphere; Glovebox;

DOI:10.1002/anie.201908931

upstream raw materials:

para-fluorostyrene

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

1-ethynyl-4-fluorobenzene

bis(pinacol)diborane

Downstream raw materials:

methyl (2E,4E)-5-((p-methyl)phenyl)penta-2,4-dienoate

(2E,4E)-5-(4-Fluoro-phenyl)-penta-2,4-dienoic acid methyl ester

Refernces

• 1、 -. "Synthesis method of alkenyl borate". Paragraph 0012; 0048-0052. . Retrieved 2021/10/30.
• 2、 Bismuto, Alessandro,Cowley, Michael J.,Thomas, Stephen P.. "Zwitterion-Initiated Hydroboration of Alkynes and Styrene". supporting information. p. 2382 - 2385. Retrieved 2021/01/18.