Methyl 5-Bromo-2-hydroxy-3-propionylbenzoate

Base Information

• Chemical Name: Methyl 5-Bromo-2-hydroxy-3-propionylbenzoate
• CAS No.: 91099-82-0
• Molecular Formula: C11H11BrO4
• Molecular Weight: 287.11
• Hs Code.: 2918990090
• Mol file: 91099-82-0.mol

Synonyms:Methyl 5-BroMo-2-hydroxy-3-propionylbenzoate

Chemical Property of Methyl 5-Bromo-2-hydroxy-3-propionylbenzoate

Chemical Property:

• PSA: 63.60000
• LogP: 2.53400
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl 5-bromo-2-hydroxy-3-propionylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5-Bromo-2-hydroxy-3-propionylbenzoate

There total 1 articles about Methyl 5-Bromo-2-hydroxy-3-propionylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

5-bromo-2-hydroxy-benzoic acid methyl ester (4068-76-2) + propionyl chloride (79-03-8) → methyl 5-bromo-3-propionylsalicylate (91099-82-0)

Guidance literature:

aluminium trichloride; In water;

Reference yield: 80.0%

methyl 5-bromo-3-propionylsalicylate (91099-82-0) + phenylmagnesium bromide (100-58-3) → methyl 2-hydroxy-3-propionyl-5-phenylbenzoate (1462903-80-5)

Guidance literature:

phenylmagnesium bromide; With titanium(IV) tetraethanolate; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

methyl 5-bromo-3-propionylsalicylate; With tributylphosphine; cobalt(II) chloride; In tetrahydrofuran; at 20 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ol402599f

Reference yield: 70.4%

methyl 5-bromo-3-propionylsalicylate (91099-82-0) + benzoyl chloride (98-88-4) → 6-bromo-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid (91830-42-1)

Guidance literature:

With sodium benzoate; at 160 - 170 ℃; for 6h;

upstream raw materials:

5-bromo-2-hydroxy-benzoic acid methyl ester

propionyl chloride

Downstream raw materials:

methyl 6-bromo-3-methylflavone-8-carboxylate

β-piperidinoethyl 5-bromo-3-propionylsalicylate

methyl 2-hydroxy-3-propionyl-5-phenylbenzoate

6-bromo-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid

Refernces

• 1、 -. "3-Propionylsalicylic acid derivatives and process for the preparation of the same". . . Retrieved 2008/06/13.