Dacemazine

Base Information

• Chemical Name: Dacemazine
• CAS No.: 518-61-6
• Molecular Formula: C₁₆H₁₆N₂OS
• Molecular Weight: 284.382
• Hs Code.: 2934300000
• UNII: 88D34UY0QI
• DSSTox Substance ID: DTXSID70199733
• Nikkaji Number: J6.586B
• Wikipedia: Dacemazine
• Wikidata: Q5207591
• NCI Thesaurus Code: C73047
• ChEMBL ID: CHEMBL2107547
• Mol file: 518-61-6.mol

Synonyms:Dacemazine;Ahistan;518-61-6;Dacemazine [INN];Histantin richter;Dacemazinum [Latin];Dacemazina [Spanish];Dacemazina;Dacemazinum;Dimethylglycylphenothiazine;10-N,N-Dimethylglycylphenothiazine;10-((Dimethylamino)acetyl)-10H-phenothiazine;Dimethylaminoacetylphenothiazine;10-(Dimethylaminoacetyl)phenothiazine;10-(N,N-Dimethylglycyl)phenothiazine;BRN 0027765;UNII-88D34UY0QI;88D34UY0QI;C16H16N2OS;Phenothiazine, 10-N,N-dimethylglycyl-;10H-Phenothiazine, 10-((dimethylamino)acetyl)-;4-27-00-01272 (Beilstein Handbook Reference);2-(dimethylamino)-1-phenothiazin-10-ylethanone;AHISTAN [MI];SCHEMBL141968;CHEMBL2107547;DTXSID70199733;AKOS040751382;LS-105507;Q5207591

Chemical Property of Dacemazine

Chemical Property:

• Vapor Pressure: 1.48E-09mmHg at 25°C
• Melting Point: 144-145°
• Refractive Index: 1.648
• Boiling Point: 484.9 °C at 760 mmHg
• PKA: 6.86±0.28(Predicted)
• Flash Point: 247 °C
• PSA: 48.85000
• Density: 1.246 g/cm³
• LogP: 3.44250
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 284.09833431
• Heavy Atom Count: 20
• Complexity: 338

Purity/Quality:

99% ^*data from raw suppliers

10-[(DIMETHYLAMINO)ACETYL]-10H-PHENOTHIAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CC(=O)N1C2=CC=CC=C2SC3=CC=CC=C31

Technology Process of Dacemazine

There total 3 articles about Dacemazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10-chloroacetylphenothiazine (786-50-5) + dimethyl amine (124-40-3) → 10-(N,N-dimethyl-glycyl)-10H-phenothiazine (518-61-6)

Guidance literature:

With benzene;

Reference yield:

10H-phenothiazine (92-84-2) → 10-(N,N-dimethyl-glycyl)-10H-phenothiazine (518-61-6)

Guidance literature:

Multi-step reaction with 2 steps

2: benzene

With benzene;

Reference yield:

→ 10-(N,N-dimethyl-glycyl)-10H-phenothiazine (518-61-6)

Guidance literature:

upstream raw materials:

10-chloroacetylphenothiazine

dimethyl amine

10H-phenothiazine