2-(4-Methoxyphenoxy)-N,N-dimethylethanamine

Base Information

• Chemical Name: 2-(4-Methoxyphenoxy)-N,N-dimethylethanamine
• CAS No.: 51344-12-8
• Molecular Formula: C11H17NO2
• Molecular Weight: 195.261
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID10567937
• Nikkaji Number: J618.352B
• Wikidata: Q72517432
• Mol file: 51344-12-8.mol

Synonyms:2-(4-Methoxyphenoxy)-N,N-dimethylethanamine;51344-12-8;DTXSID10567937;AMY10478;BCA34412;MFCD18800941;AKOS015891362;Ethanamine,2-(4-methoxyphenoxy)-N,N-dimethyl-;L10073;2-(4-Methoxyphenoxy)-N,N-dimethylethan-1-amine

Chemical Property of 2-(4-Methoxyphenoxy)-N,N-dimethylethanamine

Chemical Property:

• Boiling Point: 281℃
• PKA: 8.55±0.28(Predicted)
• Flash Point: 98℃
• PSA: 21.70000
• Density: 1.005
• LogP: 1.63560
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 195.125928785
• Heavy Atom Count: 14
• Complexity: 142

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Methoxyphenoxy)-N,N-dimethylethanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCOC1=CC=C(C=C1)OC

Technology Process of 2-(4-Methoxyphenoxy)-N,N-dimethylethanamine

There total 9 articles about 2-(4-Methoxyphenoxy)-N,N-dimethylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

N,N-dimethyl-2-(4'-methoxyphenoxy)ethanamide (137325-67-8) → N,N-dimethyl-2-(4'-methoxyphenoxy)aminoethane (51344-12-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Ambient temperature;

Reference yield:

2-(N,N-dimethylamino)ethanol (108-01-0) + 4-methoxy-phenol (150-76-5) + Diethyl carbonate (105-58-8,76619-83-5) → 1-ethoxy-4-methoxybenzene (5076-72-2) + N,N-dimethyl-2-(4'-methoxyphenoxy)aminoethane (51344-12-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 200 ℃; for 8h; under 12001.2 Torr; Autoclave;

DOI:10.1002/ejoc.202100328

Reference yield:

(2-chloroethyl)dimethylamine hydrochloride (4584-46-7) + 4-methoxy-phenol (150-76-5) → N,N-dimethyl-2-(4'-methoxyphenoxy)aminoethane (51344-12-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

DOI:10.1021/jm040154f

upstream raw materials:

1-(2-bromoethoxy)-4-methoxybenzene

dimethyl amine

N,N-dimethyl-2-(4'-methoxyphenoxy)ethanamide

(2-chloroethyl)dimethylamine hydrochloride

Downstream raw materials:

Ethyl-[2-(4-methoxy-phenoxy)-ethyl]-dimethyl-ammonium; iodide

C₃₂H₅₄N₂O₄⁽²⁺⁾*2Br^(1-)

N,N-dimethyl 4-hydroxyphenyl-2-oxyethylamine