5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine

Base Information

Chemical Name:5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
CAS No.:81265-93-2
Molecular Formula:C₄₄H₄₉N₅O₇Si
Molecular Weight:787.988
Hs Code.:
DSSTox Substance ID:DTXSID10551634
Nikkaji Number:J741.055G
Wikidata:Q82431405
Mol file:81265-93-2.mol

Synonyms:81265-93-2;5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine;N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide;5'-O-DMT-2'-O-TBDMS-N6-Bz-adenosine;N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]purin-6-yl]benzamide;N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine;MFCD00080294;n6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-dmt-adenosine;SCHEMBL6396836;DTXSID10551634;EX-A3337;AKOS015999124;AC-32204;DS-14584;HY-21601;PD157918;5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine?;CS-0021845;F13860;J-700110;J-700368;5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-n6-benzoyl-adenosine;N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine;5'-O-(4,4'-Dimethoxytrityl) 2'-O-[(1,1-dimethylethyl)-dimethylsilyl]-N6- benzoyl-adenosine;N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[tert-butyl(dimethyl)silyl]adenosine

Suppliers and Price of 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5''-O-DMT-2''-O-TBDMS-N-Bz-Adenosine
2.5g
$ 200.00

Matrix Scientific
N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 95+%
1g
$ 50.00

Matrix Scientific
N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 95+%
5g
$ 150.00

Crysdot
5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine 95+%
25g
$ 619.00

Crysdot
5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine 95+%
10g
$ 262.00

ChemScene
5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
1g
$ 104.00

ChemScene
5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
10g
$ 455.00

ChemScene
5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
5g
$ 312.00

Chemenu
N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 95%
5g
$ 153.00

Chemenu
N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 95%
25g
$ 585.00

Total 35 raw suppliers

Chemical Property of 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine

Chemical Property:

PKA:7.87±0.43(Predicted)
PSA：139.08000
Density:1.23±0.1 g/cm3(Predicted)
LogP:7.82620
Storage Temp.:2-8°C
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:14
Exact Mass:787.34012545
Heavy Atom Count:57
Complexity:1250

Purity/Quality:

98%, ^*data from raw suppliers

5''-O-DMT-2''-O-TBDMS-N-Bz-Adenosine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O
Isomeric SMILES:CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O
Uses 5''-O-DMT-2''-O-TBDMS-N-Bz-Adenosine (CAS# 81265-93-2) is a fluorescent adenosine-containing compound which is often used in for DNA/RNA modifications for detection or the addition of synthetic oligonucleotide blocks.

Technology Process of 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine

There total 14 articles about 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 69504-07-0
N⁶-benzoyl-2'-O-(tert-butyldimethylsilyl)adenosine

: 129681-71-6,81265-93-2
5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine

Guidance literature:: With pyridine; at 0 ℃;
DOI:10.1081/NCN-120022724

Reference yield: 82.0%

: 129666-75-7,81246-82-4
6-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)adenosine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 129681-71-6,81265-93-2
5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine

Guidance literature:: With (2R,4S)-3-((R)-cyclopentyl(1-methyl-1H-imidazol-2-yl)methyl)-4-isopropyl-2-methoxyoxazolidine; N,N-diisopropylethylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol402023c