(R)-Hydroxy-(4-fluoro-phenyl)-acetic acid ethyl ester

Base Information

Chemical Name:(R)-Hydroxy-(4-fluoro-phenyl)-acetic acid ethyl ester
CAS No.:32222-46-1
Molecular Formula:C₉H₉FO₃
Molecular Weight:184.167
Hs Code.:
Mol file:32222-46-1.mol

Synonyms:(R)-Ethyl 2-(4-fluorophenyl)-2-hydroxyacetate;(R)-Hydroxy-(4-fluoro-phenyl)-acetic acid ethyl ester;Benzeneacetic acid, 4-fluoro-α-hydroxy-, methyl ester, (αR)-

Suppliers and Price of (R)-Hydroxy-(4-fluoro-phenyl)-acetic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(R)-Ethyl2-(4-fluorophenyl)-2-hydroxyacetate 95+%
1g
$ 455.00

Alichem
(R)-Ethyl2-(4-fluorophenyl)-2-hydroxyacetate
1g
$ 405.48

Total 5 raw suppliers

Chemical Property of (R)-Hydroxy-(4-fluoro-phenyl)-acetic acid ethyl ester

Chemical Property:

Boiling Point:268.8±25.0 °C(Predicted)
PKA:12.12±0.20(Predicted)
Density:1.272±0.06 g/cm3(Predicted)
Storage Temp.:2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(R)-Ethyl2-(4-fluorophenyl)-2-hydroxyacetate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-Hydroxy-(4-fluoro-phenyl)-acetic acid ethyl ester

There total 30 articles about (R)-Hydroxy-(4-fluoro-phenyl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 156276-23-2
methyl (p-fluorobenzoyl)formate

: 127709-19-7,32222-46-1
methyl 4-fluoro-α-hydroxyphenylacetate

Guidance literature:: With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II); hydrogen; sodium hydrogencarbonate; In methanol; at 25 ℃; for 12h; under 7500.75 Torr; chemoselective reaction; Glovebox; Autoclave;
DOI:10.1055/s-0035-1561971

Reference yield: 94.0%

: 67-56-1
methanol

: N-[2-(4-fluorophenyl)-2-oxoacetyl]benzamide

: 32222-46-1
(4-fluoro-phenyl)-hydroxy-acetic acid methyl ester

Guidance literature:: With [RuCl(TsDPEN)(hexamethylbenzene)]; sodium formate; at 40 ℃; for 3h; enantioselective reaction;
DOI:10.1002/cctc.201500906