(2S)-2-(methoxymethyl)morpholine

Base Information

• Chemical Name: (2S)-2-(methoxymethyl)morpholine
• CAS No.: 157791-20-3
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.173004
• DSSTox Substance ID: DTXSID00435555
• Wikidata: Q72490515
• Mol file: 157791-20-3.mol

Synonyms:(2S)-2-(methoxymethyl)morpholine;157791-20-3;(S)-2-(Methoxymethyl)morpholine;Morpholine, 2-(methoxymethyl)-, (2S)-;SCHEMBL272144;(2S)-2-Methoxymethyl-morpholine;DTXSID00435555;ZPELJYYPPKJKBE-LURJTMIESA-N;CS-0302168;EN300-2991470

Chemical Property of (2S)-2-(methoxymethyl)morpholine

Chemical Property:

• Boiling Point: 195.8±20.0 °C(Predicted)
• PKA: 8.56±0.40(Predicted)
• PSA: 30.49000
• Density: 0.954±0.06 g/cm3(Predicted)
• LogP: -0.05000
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 131.094628657
• Heavy Atom Count: 9
• Complexity: 77.5

Purity/Quality:

98%min ^*data from raw suppliers

(2S)-2-(Methoxymethyl)morpholine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC1CNCCO1
• Isomeric SMILES: COC[C@@H]1CNCCO1

Technology Process of (2S)-2-(methoxymethyl)morpholine

There total 7 articles about (2S)-2-(methoxymethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.05%

tert-butyl 2-(methoxymethyl)morpholine-4-carboxylate → 2-(methoxymethyl)morpholine (156121-15-2,157791-20-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield: 10.0%

Tau (107-35-7) + R(-)-glycidyl methyl ether (64491-70-9) → (R)-2-(methoxymethyl)morpholine (157791-21-4,157791-20-3)

Guidance literature:

With sodium hydroxide; In methanol; at 50 ℃; for 21.25h;

Reference yield:

4-benzyl-2-(methoxymethyl)morpholine (143804-53-9) → 2-(methoxymethyl)morpholine (156121-15-2,157791-20-3)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; under 3677.5 Torr; Ambient temperature;

upstream raw materials:

4-benzyl-2-(methoxymethyl)morpholine

1-[Benzyl-(2-hydroxy-ethyl)-amino]-3-methoxy-propan-2-ol

N-benzyl-2-chloromethylmorpholine

4-(tert-butyl) 2-ethyl morpholine-2,4-dicarboxylate