3-(4-Chlorophenyl)-6-methoxypyridazine

Base Information

• Chemical Name: 3-(4-Chlorophenyl)-6-methoxypyridazine
• CAS No.: 70751-01-8
• Molecular Formula: C11H9ClN2O
• Molecular Weight: 220.658
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40572837
• Wikidata: Q82461332
• Mol file: 70751-01-8.mol

Synonyms:3-(4-chlorophenyl)-6-methoxypyridazine;70751-01-8;DTXSID40572837

Chemical Property of 3-(4-Chlorophenyl)-6-methoxypyridazine

Chemical Property:

• PSA: 35.01000
• LogP: 2.80560
• Storage Temp.: 2-8°C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 220.0403406
• Heavy Atom Count: 15
• Complexity: 195

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Chlorophenyl)-6-methoxypyridazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NN=C(C=C1)C2=CC=C(C=C2)Cl

Technology Process of 3-(4-Chlorophenyl)-6-methoxypyridazine

There total 5 articles about 3-(4-Chlorophenyl)-6-methoxypyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-chloro-6-methoxypyridazine (1722-10-7) + 1-Chloro-4-iodobenzene (637-87-6) → 3-Methoxy-6-(4-chlorophenyl)pyridazine (70751-01-8)

Guidance literature:

3-chloro-6-methoxypyridazine; With zinc trimethylacetate; cobalt(II) chloride; zinc; In benzonitrile; at 25 ℃; for 12h; Inert atmosphere;

1-Chloro-4-iodobenzene; With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; benzonitrile; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1055/a-1534-0624

Reference yield: 72.0%

3-methoxy-6-(methylthio)pyridazine (40953-94-4) + C6H4ClIZn*ClLi → 3-Methoxy-6-(4-chlorophenyl)pyridazine (70751-01-8)

Guidance literature:

3-methoxy-6-(methylthio)pyridazine; With bis(acetylacetonate)nickel(II); bis[2-(diphenylphosphino)phenyl] ether; In tetrahydrofuran; for 0.166667h; Inert atmosphere;

C₆H₄ClIZn*ClLi; In tetrahydrofuran; at 25 ℃; for 6h; Inert atmosphere;

DOI:10.1002/chem.201002850

Reference yield: 60.0%

3-chloro-6-methoxypyridazine (1722-10-7) + 4-Chlorophenylboronic acid (1679-18-1) → 3-Methoxy-6-(4-chlorophenyl)pyridazine (70751-01-8)

Guidance literature:

With water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; at 110 ℃; for 16h;

DOI:10.1055/s-1999-3528

upstream raw materials:

3-chloro-6-methoxypyridazine

4-Chlorophenylboronic acid

3-methoxy-6-(methylthio)pyridazine

1-Chloro-4-iodobenzene