Benzyl 3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:Benzyl 3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate
CAS No.:1017789-40-0
Molecular Formula:C13H18N2O3
Molecular Weight:250.298
Hs Code.:2933990090
DSSTox Substance ID:DTXSID501173352
Mol file:1017789-40-0.mol

Synonyms:1017789-40-0;Benzyl 3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate;1-Cbz-3-amino-4-(hydroxymethyl)pyrrolidine;1-Cbz-3-Amino-4-hydroxymethylpyrrolidine;3-amino-4-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester;252770-09-5;1-Pyrrolidinecarboxylic acid, 3-amino-4-(hydroxymethyl)-, phenylmethyl ester;SCHEMBL1586777;Benzyl3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 3-amino-4-(hydroxymethyl)-, phenylmethyl ester, (3R,4R)-rel-;YXCPNFNWSNFFFZ-UHFFFAOYSA-N;DTXSID501173352;CS-B0700;MFCD09991641;1-Pyrrolidinecarboxylic acid,3-amino-4-(hydroxymethyl)-,phenylmethyl ester;AKOS022180543;PB42400;AS-37169;DB-023955;A897055;Phenylmethyl 3-amino-4-(hydroxymethyl)-1-pyrrolidinecarboxylate

Suppliers and Price of Benzyl 3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Cbz-3-amino-4-hydroxymethylpyrrolidine
50mg
$ 90.00

Crysdot
Benzyl3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate 97%
5g
$ 893.00

ChemScene
Benzyl3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate
1g
$ 428.00

ChemScene
Benzyl3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate
250mg
$ 214.00

ChemScene
Benzyl3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate
100mg
$ 128.00

Chemenu
Benzyl3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate 95+%
5g
$ 835.00

American Custom Chemicals Corporation
1-CBZ-3-AMINO-4-HYDROXYMETHYLPYRROLIDINE 95.00%
1G
$ 1052.67

AK Scientific
1-Cbz-3-Amino-4-hydroxymethylpyrrolidine
1g
$ 757.00

Total 9 raw suppliers

Chemical Property of Benzyl 3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate

Chemical Property:

PSA：75.79000
LogP:1.21280
Storage Temp.:2-8°C(protect from light)
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:250.13174244
Heavy Atom Count:18
Complexity:279

Purity/Quality:

97% ^*data from raw suppliers

1-Cbz-3-amino-4-hydroxymethylpyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(CN1C(=O)OCC2=CC=CC=C2)N)CO

Technology Process of Benzyl 3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate

There total 6 articles about Benzyl 3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₆N₂O₃

: 1017789-40-0,252770-09-5,255823-06-4
3-amino-4-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With hydrogen; Raney Ni; In ethanol; pentan-1-ol; for 4h; under 3102.97 Torr;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1017789-40-0,252770-09-5,255823-06-4
3-amino-4-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / toluene; water / 4 h / 0 - 20 °C / Inert atmosphere

2.1: potassium hydroxide / N-benzyl-N,N,N-triethylammonium chloride / toluene / 48 h / 50 °C / Inert atmosphere

3.1: formic acid / 20 °C / Inert atmosphere

4.1: hydroxylamine hydrochloride; sodium acetate / acetonitrile; water / 20 °C / Inert atmosphere

5.1: pentan-1-ol / 20 h / 135 °C / Inert atmosphere

5.2: Raney Ni / 4 h / 3102.97 Torr

With formic acid; hydroxylamine hydrochloride; sodium acetate; potassium hydroxide; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In pentan-1-ol; water; toluene; acetonitrile;

Reference yield:

: 569682-60-6
benzyl N-(2,2-dimethoxyethyl)-N-(prop-2-en-1-yl)carbamate

: 1017789-40-0,252770-09-5,255823-06-4
3-amino-4-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: formic acid / 20 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium acetate / acetonitrile; water / 20 °C / Inert atmosphere

3.1: pentan-1-ol / 20 h / 135 °C / Inert atmosphere

3.2: Raney Ni / 4 h / 3102.97 Torr

With formic acid; hydroxylamine hydrochloride; sodium acetate; In pentan-1-ol; water; acetonitrile;