3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine

Base Information

Chemical Name:3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine
CAS No.:1255099-67-2
Molecular Formula:C18H26N2O5
Molecular Weight:350.415
Hs Code.:
Mol file:1255099-67-2.mol

Synonyms:3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine

Suppliers and Price of 3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Boc-Amino-1-Cbz-4-Hydroxymethyl-Pyrrolidine
50mg
$ 200.00

TRC
3-Boc-Amino-1-Cbz-4-Hydroxymethyl-Pyrrolidine
10mg
$ 65.00

Crysdot
Benzyl3-((tert-butoxycarbonyl)amino)-4-(hydroxymethyl)pyrrolidine-1-carboxylate 97%
1g
$ 480.00

Alichem
Benzyl3-((tert-butoxycarbonyl)amino)-4-(hydroxymethyl)pyrrolidine-1-carboxylate
5g
$ 1849.88

Alichem
Benzyl3-((tert-butoxycarbonyl)amino)-4-(hydroxymethyl)pyrrolidine-1-carboxylate
1g
$ 664.89

AK Scientific
Benzyl3-((tert-butoxycarbonyl)amino)-4-(hydroxymethyl)pyrrolidine-1-carboxylate
250mg
$ 363.00

Total 9 raw suppliers

Chemical Property of 3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine

Chemical Property:

Boiling Point:510.5±50.0 °C(Predicted)
PKA:12.01±0.40(Predicted)
PSA：88.10000
Density:1.22±0.1 g/cm3(Predicted)
LogP:2.46940
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Boc-Amino-1-Cbz-4-Hydroxymethyl-Pyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine

There total 7 articles about 3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1017789-40-0,252770-09-5,255823-06-4
3-amino-4-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

: 1255099-67-2,246510-67-8
3-tert-butoxycarbonylamino-4-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With sodium hydrogencarbonate; In ethanol; pentan-1-ol; water; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1255099-67-2,246510-67-8
3-tert-butoxycarbonylamino-4-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / toluene; water / 4 h / 0 - 20 °C / Inert atmosphere

2.1: potassium hydroxide / N-benzyl-N,N,N-triethylammonium chloride / toluene / 48 h / 50 °C / Inert atmosphere

3.1: formic acid / 20 °C / Inert atmosphere

4.1: hydroxylamine hydrochloride; sodium acetate / acetonitrile; water / 20 °C / Inert atmosphere

5.1: pentan-1-ol / 20 h / 135 °C / Inert atmosphere

5.2: Raney Ni / 4 h / 3102.97 Torr

6.1: sodium hydrogencarbonate / ethanol; water; pentan-1-ol / 15 h / 20 °C / Inert atmosphere

With formic acid; hydroxylamine hydrochloride; sodium acetate; sodium hydrogencarbonate; potassium hydroxide; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In ethanol; pentan-1-ol; water; toluene; acetonitrile;

Reference yield:

: 569682-60-6
benzyl N-(2,2-dimethoxyethyl)-N-(prop-2-en-1-yl)carbamate

: 1255099-67-2,246510-67-8
3-tert-butoxycarbonylamino-4-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: formic acid / 20 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium acetate / acetonitrile; water / 20 °C / Inert atmosphere

3.1: pentan-1-ol / 20 h / 135 °C / Inert atmosphere

3.2: Raney Ni / 4 h / 3102.97 Torr

4.1: sodium hydrogencarbonate / ethanol; water; pentan-1-ol / 15 h / 20 °C / Inert atmosphere

With formic acid; hydroxylamine hydrochloride; sodium acetate; sodium hydrogencarbonate; In ethanol; pentan-1-ol; water; acetonitrile;