3-tert-butoxycarbonylamino-4-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:3-tert-butoxycarbonylamino-4-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid benzyl ester
CAS No.:1293940-34-7
Molecular Formula:C₁₉H₂₈N₂O₇S
Molecular Weight:428.507
Hs Code.:

Synonyms:3-tert-butoxycarbonylamino-4-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

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Chemical Property of 3-tert-butoxycarbonylamino-4-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

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Technology Process of 3-tert-butoxycarbonylamino-4-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

There total 8 articles about 3-tert-butoxycarbonylamino-4-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1255099-67-2,246510-67-8
3-tert-butoxycarbonylamino-4-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

: 124-63-0
methanesulfonyl chloride

: 1293940-34-7
3-tert-butoxycarbonylamino-4-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 22.3333h; Inert atmosphere;

Reference yield:

: 114790-39-5
benzyl N-(2,2-dimethoxyethyl)carbamate

: 1293940-34-7
3-tert-butoxycarbonylamino-4-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / N-benzyl-N,N,N-triethylammonium chloride / toluene / 48 h / 50 °C / Inert atmosphere

2.1: formic acid / 20 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / acetonitrile; water / 20 °C / Inert atmosphere

4.1: pentan-1-ol / 20 h / 135 °C / Inert atmosphere

4.2: Raney Ni / 4 h / 3102.97 Torr

5.1: sodium hydrogencarbonate / ethanol; water; pentan-1-ol / 15 h / 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 22.33 h / 0 - 20 °C / Inert atmosphere

With formic acid; hydroxylamine hydrochloride; sodium acetate; sodium hydrogencarbonate; triethylamine; potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In ethanol; dichloromethane; pentan-1-ol; water; toluene; acetonitrile;

Reference yield:

: 370880-75-4
benzyl N-(2-oxoethyl)-N-(prop-2-en-1-yl)carbamate

: 1293940-34-7
3-tert-butoxycarbonylamino-4-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium acetate / acetonitrile; water / 20 °C / Inert atmosphere

2.1: pentan-1-ol / 20 h / 135 °C / Inert atmosphere

2.2: Raney Ni / 4 h / 3102.97 Torr

3.1: sodium hydrogencarbonate / ethanol; water; pentan-1-ol / 15 h / 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 22.33 h / 0 - 20 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium acetate; sodium hydrogencarbonate; triethylamine; In ethanol; dichloromethane; pentan-1-ol; water; acetonitrile;