Hydroxyhomosildenafil

Base Information

• Chemical Name: Hydroxyhomosildenafil
• CAS No.: 139755-85-4
• Molecular Formula: C23H32N6O5S
• Molecular Weight: 504.61
• Hs Code.: 29339900
• Mol file: 139755-85-4.mol

Synonyms:Hydroxyhomo Sildenafil;

Chemical Property of Hydroxyhomosildenafil

Chemical Property:

• Vapor Pressure: 2.08E-22mmHg at 25°C
• Melting Point: 183-185 C
• Boiling Point: 730.6oC at 760 mmHg
• PKA: 10.05±0.20(Predicted)
• Flash Point: 395.7oC
• PSA: 142.03000
• Density: 1.42g/cm3
• LogP: 1.93000
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Hydroxyhomo Sildenafil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A Sildenafil (S435000) analog, enhances male sexual function. A Sildenafil (S435000) analog, enhances male sexual function

Technology Process of Hydroxyhomosildenafil

There total 9 articles about Hydroxyhomosildenafil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-hydroxyethyl)piperazine (103-76-4) + 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (139756-22-2) → 5-[2-ethoxy-5-[4-(2-hydroxyethyl)-1-piperazinyl-sulphonyl]phenyl}-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (139755-85-4)

Guidance literature:

With triethylamine; In ethanol; at 30 ℃; for 0.0833333h; microwave irradiation;

DOI:10.1021/jm701400r

Reference yield:

4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide (139756-02-8) → 5-[2-ethoxy-5-[4-(2-hydroxyethyl)-1-piperazinyl-sulphonyl]phenyl}-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (139755-85-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N, DMAP / CH₂Cl₂

2: NaOH / ethanol; H₂O

3: 1) ClSO₃H / 1), 2) EtOH

With chlorosulfonic acid; dmap; sodium hydroxide; triethylamine; In ethanol; dichloromethane; water;

DOI:10.1016/0960-894X(96)00323-X

Reference yield:

2-ethoxybenzoyl chloride (42926-52-3) → 5-[2-ethoxy-5-[4-(2-hydroxyethyl)-1-piperazinyl-sulphonyl]phenyl}-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (139755-85-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N, DMAP / CH₂Cl₂

2: NaOH / ethanol; H₂O

3: 1) ClSO₃H / 1), 2) EtOH

With chlorosulfonic acid; dmap; sodium hydroxide; triethylamine; In ethanol; dichloromethane; water;

DOI:10.1016/0960-894X(96)00323-X

upstream raw materials:

1-(2-hydroxyethyl)piperazine

5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one

2-ethoxybenzoyl chloride

4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

Downstream raw materials:

C₃₃H₅₀N₆O₆S

5-{2-ethoxy-5-[(4-chlorobutyric acid ethyl ester)piperazin-1-ylsulfonyl]phenyl}-1-methyl-3-N-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Refernces

• 1、 Flores Toque, Haroldo A.,Priviero, Fernanda B. M.,Teixeira, Cleber E.,Perissutti, Elisa,Fiorino, Ferdinando,Severino, Beatrice,Frecentese, Francesco,Lorenzetti, Raquel,Baracat, Juliana S.,Santagada, Vincenzo,Caliendo, Giuseppe,Antunes, Edson,De Nucci, Gilberto. "Synthesis and pharmacological evaluations of sildenafil analogues for treatment of erectile dysfunction". . p. 2807 - 2815. Retrieved 2008/12/22.
• 2、 -. "Methods and compositions for treating diseases and conditions of the eye". . . Retrieved 2008/06/13.