2-Methyl-3-nitropyridin-4-ol

Base Information

Chemical Name:2-Methyl-3-nitropyridin-4-ol
CAS No.:18614-66-9
Molecular Formula:C6H6N2O3
Molecular Weight:154.125
Hs Code.:2933399990
DSSTox Substance ID:DTXSID50596342
Wikidata:Q82491573
Mol file:18614-66-9.mol

Synonyms:2-methyl-3-nitropyridin-4-ol;18614-66-9;4-Hydroxy-2-methyl-3-nitropyridine;2-methyl-3-nitro-1H-pyridin-4-one;MFCD13181715;4-Pyridinol, 2-methyl-3-nitro-;2-Methyl-3-nitropyridin-4(1H)-one;SCHEMBL2596971;DTXSID50596342;SJIBWWCVKBIGAJ-UHFFFAOYSA-N;AMY10232;AKOS025395171;AKOS037645638;AS-61937;SY273269;DB-082845;2-methyl-3-nitro-1,4-dihydropyridin-4-one;CS-0047170;EN300-106659;W15244

Suppliers and Price of 2-Methyl-3-nitropyridin-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alichem
4-Hydroxy-2-methyl-3-nitropyridine
250mg
$ 940.80

Alichem
4-Hydroxy-2-methyl-3-nitropyridine
1g
$ 3097.65

Alichem
4-Hydroxy-2-methyl-3-nitropyridine
500mg
$ 1634.45

AK Scientific
2-Methyl-3-nitropyridin-4-ol
2.5g
$ 1381.00

AK Scientific
2-Methyl-3-nitropyridin-4-ol
500mg
$ 590.00

Total 9 raw suppliers

Chemical Property of 2-Methyl-3-nitropyridin-4-ol

Chemical Property:

Melting Point:273 °C(Solv: water (7732-18-5))
Boiling Point:354.1±37.0 °C(Predicted)
PKA:-0.04±0.20(Predicted)
PSA：78.94000
Density:1.411±0.06 g/cm3(Predicted)
LogP:1.52700
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:154.03784206
Heavy Atom Count:11
Complexity:272

Purity/Quality:

≥95% ^*data from raw suppliers

4-Hydroxy-2-methyl-3-nitropyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=O)C=CN1)[N+](=O)[O-]

Technology Process of 2-Methyl-3-nitropyridin-4-ol

There total 10 articles about 2-Methyl-3-nitropyridin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 18615-86-6
2-Methyl-4-hydroxypyridine

: 18614-66-9
2-methyl-3-nitro-4-pyridinol

Guidance literature:: With sulfuric acid; nitric acid; at 130 ℃; for 2h;

Reference yield:

: 5470-66-6
2-methyl-4-nitropyridine N-oxide

: 18614-66-9
2-methyl-3-nitro-4-pyridinol

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / PtO₂ / acetic acid / 2068.6 Torr

2: 40 percent / HNO₃, NaNO₂ / H₂O / <20 deg C

3: HNO₃, H₂SO₄ / 2 h / Heating

With sulfuric acid; hydrogen; nitric acid; sodium nitrite; platinum(IV) oxide; In water; acetic acid;
DOI:10.1021/jm00131a010

Reference yield:

: 24103-75-1
4-methoxy-2-methylpyridine

: 18614-67-0
2-methyl-5-nitropyridin-4-ol

: 18614-66-9
2-methyl-3-nitro-4-pyridinol

Guidance literature:: 4-methoxy-2-methylpyridine; With sulfuric acid; nitric acid; at 0 - 65 ℃; for 16h; Sealed tube;

With hydrogen bromide; at 100 ℃; for 2h; Overall yield = 68 %; Overall yield = 250mg;