(R)-Butyryl Carnitine Chloride

Base Information

• Chemical Name: (R)-Butyryl Carnitine Chloride
• CAS No.: 162067-50-7
• Molecular Formula: C11H22NO4.Cl
• Molecular Weight: 267.75000
• Mol file: 162067-50-7.mol

Synonyms:(R)-Butyryl Carnitine Chloride;L-CARNITINE:HCL, O-BUTYRYL;(2R)-3-Carboxy-N,N,N-triMethyl-2-(1-oxobutoxy)-1-propanaMiniuM Chloride;Butyrylcarnitine Chloride;L-Carnitine Butyryl Ester Chloride;n-Butyryl-L(-)-carnitine Chloride

Chemical Property of (R)-Butyryl Carnitine Chloride

Chemical Property:

• Melting Point: 163-165 C
• PSA: 66.43000
• LogP: 0.34650
• Storage Temp.: -20°C Freezer
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

(R)-ButyrylCarnitineChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Butyryl-L-carnitine is a butyrate ester of carnitine. It is an inhibitor of intestinal transporters, blocking carnitine uptake by the carnitine transporter and glycine transport by the amino acid transporter in human retinal pigment epithelial (HRPE) cells (IC50s = 1.5 μM and 4.6 mM, respectively).
• Uses: (R)-Butyryl Carnitine Chloride is a potential prodrug of Carnitine, used for treating seizure disorders. A potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB0,+.

Technology Process of (R)-Butyryl Carnitine Chloride

There total 2 articles about (R)-Butyryl Carnitine Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-carnitine chloride (6645-46-1) + butyryl chloride (141-75-3) → (-)-O-Butyryl-carnitin (162067-50-7)

Guidance literature:

With trifluoroacetic acid; at 40 - 50 ℃; for 20h;

DOI:10.3184/030823408X324689

Reference yield:

L-carnitine (541-15-1,44985-79-7) + Hexanoyl chloride (142-61-0) → (-)-O-Butyryl-carnitin (162067-50-7)

Guidance literature:

DOI:10.1515/bchm2.1966.343.1.231

upstream raw materials:

L-carnitine

Hexanoyl chloride

L-carnitine chloride

butyryl chloride

Refernces

• 1、 Gong, Xiao-Wei,Li, Jin-Pei,Wu, Ji-Feng,Li, Xun,Zhai, Hai-Min,Feng, Bo,Xu, Wen-Fang,Tang, Wei. "Synthesis of carnitine benzyl esters as prodrugs". experimental part. p. 327 - 330. Retrieved 2009/05/30.