methyl 5-acetyl-2-fluorobenzoate

Base Information Edit

Chemical Name:methyl 5-acetyl-2-fluorobenzoate
CAS No.:1031417-96-5
Molecular Formula:C10H9FO3
Molecular Weight:196.178
Hs Code.:
Mol file:1031417-96-5.mol

Synonyms:Methyl 5-acetyl-2-fluorobenzoate

Suppliers and Price of methyl 5-acetyl-2-fluorobenzoate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of methyl 5-acetyl-2-fluorobenzoate Edit

Chemical Property:

PSA：43.37000
LogP:1.81490

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of methyl 5-acetyl-2-fluorobenzoate

There total 4 articles about methyl 5-acetyl-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1031417-94-3
methyl 2-fluoro-5-(2-(trimethylsilyl)ethynyl)benzoate

: 7664-93-9
sulfuric acid

: 1031417-96-5
methyl 5-acetyl-2-fluorobenzoate

Guidance literature:: mercury(II) diacetate; In tetrahydrofuran; at 50 - 60 ℃; for 2h;

Reference yield: 66.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1007-15-4
4-fluoro-3-bromoacetophenone

: 1031417-96-5
methyl 5-acetyl-2-fluorobenzoate

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 24h; under 4137.29 Torr;

Reference yield:

: 146328-85-0
5-bromo-2-fluoro-benzoic acid

: 1031417-96-5
methyl 5-acetyl-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 8 h / Heating / reflux

2.1: diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / benzene / 0.5 h

2.2: 5.5 h / 10 - 60 °C

3.1: mercury(II) diacetate / tetrahydrofuran / 2 h / 50 - 60 °C

With hydrogenchloride; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; mercury(II) diacetate; In tetrahydrofuran; benzene;