RARECHEM AL BU 0001

Base Information

• Chemical Name: RARECHEM AL BU 0001
• CAS No.: 148562-11-2
• Molecular Formula: C3H8BBrO2
• Molecular Weight: 166.81
• Mol file: 148562-11-2.mol

Synonyms:3-bromopropane-1-boronate;

Chemical Property of RARECHEM AL BU 0001

Chemical Property:

• PSA: 40.46000
• LogP: 0.24420

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of RARECHEM AL BU 0001

There total 4 articles about RARECHEM AL BU 0001 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

dihydroxy-methyl-borane (13061-96-6) + 2-(3-Bromopropyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (124215-44-7) → 3-bromopropylboronic acid (148562-11-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.orglett.9b00584

Reference yield: 67.0%

diisopinocampheylborane + allyl bromide (106-95-6) → 3-bromopropylboronic acid (148562-11-2)

Guidance literature:

With water; acetaldehyde; In tetrahydrofuran; (N2); dropwise addn. of allyl bromide to suspension of Ipc2BH at 0°C; stirring for 5 h at room temperature; cooling to 0°C; addn. of CH3CHO; 15 h at room temperature; addn. of water; removal of solvent by distn. in vac.; washing with hexane;

Reference yield: 27.0%

water (7732-18-5) + boron trichloride (10294-34-5) + allyl bromide (106-95-6) → 3-bromopropylboronic acid (148562-11-2)

Guidance literature:

boron trichloride; allyl bromide; With triethylsilane; In hexane; at -78 ℃; for 0.666667h; Inert atmosphere;

water; In diethyl ether; hexane; for 0.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.08.012

upstream raw materials:

allyl bromide

water

boron trichloride

dihydroxy-methyl-borane

Downstream raw materials:

(S)-ethyl 1-(1-(tert-butyl-dimethyl-silanyloxymethyl)-3,3-dimethylbutan-2-yl)-6-(3-chloro-2-fluoro-benzyl)-7-(3-hydroxypropyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate