Butanoic acid, 3-oxo-,2-[(3,3-diphenylpropyl)MethylaMino]-1,1-diMethylethyl ester

Base Information

• Chemical Name: Butanoic acid, 3-oxo-,2-[(3,3-diphenylpropyl)MethylaMino]-1,1-diMethylethyl ester
• CAS No.: 100427-51-8
• Molecular Formula: C24H31NO3
• Molecular Weight: 381.515
• Mol file: 100427-51-8.mol

Synonyms:Butanoic acid, 3-oxo-,2-[(3,3-diphenylpropyl)MethylaMino]-1,1-diMethylethyl ester;1-[(3,3-DIPHENYLPROPYL)-METHYLAMINO]-2-METHYLPROPANE-2-YL-3-OXOBUTANOATE;

Chemical Property of Butanoic acid, 3-oxo-,2-[(3,3-diphenylpropyl)MethylaMino]-1,1-diMethylethyl ester

Chemical Property:

• PSA: 46.61000
• Density: 1.062±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 4.44130
• Solubility.: Chloroform, DCM, DMSO

Purity/Quality:

98%Min ^*data from raw suppliers

3-Oxo-butanoicAcid2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Oxo-butanoic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Ester is an intermediate in synthesizing 5-Ethyl-demethyl Lercanidipine (E913200), which is an impurity of Lercanidipine (L179000), a dihydropyridine calcium channel blocker.

Technology Process of Butanoic acid, 3-oxo-,2-[(3,3-diphenylpropyl)MethylaMino]-1,1-diMethylethyl ester

There total 3 articles about Butanoic acid, 3-oxo-,2-[(3,3-diphenylpropyl)MethylaMino]-1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + 2,N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol (100442-33-9) → 1,1,N-trimethyl-N-(3,3-diphenylpropy)-2-aminoethyl acetoacetate (100427-51-8)

Guidance literature:

In toluene; at 80 ℃; for 2h;

DOI:10.1016/S0223-5234(98)80015-9

Reference yield:

acetoacetic acid methyl ester (105-45-3) + 2,N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol (100442-33-9) → 1,1,N-trimethyl-N-(3,3-diphenylpropy)-2-aminoethyl acetoacetate (100427-51-8)

Guidance literature:

zinc; In xylene; at 25 - 145 ℃; for 7h;

Reference yield:

N-methyl-3,3-diphenylpropylamine (28075-29-8) → 1,1,N-trimethyl-N-(3,3-diphenylpropy)-2-aminoethyl acetoacetate (100427-51-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / xylene / 8.5 h / Heating

2: 72 percent / toluene / 2 h / 80 °C

In toluene; xylene;

DOI:10.1016/S0223-5234(98)80015-9

upstream raw materials:

4-methyleneoxetan-2-one

2,N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol

N-methyl-3,3-diphenylpropylamine

acetoacetic acid methyl ester

Downstream raw materials:

2-[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-[(3,3-diphenyl-propyl)-methyl-amino]-1,1-dimethyl-ethyl ester

2-[(3-nitrophenyl)methylene]-3-oxobutanoic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethyl ethyl ester hydrochloride

lercanidipine hydrochloride

2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl-propyl)-methyl-amino]-1,1-dimethyl-ethyl} ester 5-ethyl ester