Technology Process of 2-fluoro-5-vinylpyridine
There total 3 articles about 2-fluoro-5-vinylpyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at -30 ℃;
for 3h;
Inert atmosphere;
2-fluoro-5-formylpyridine;
In
tetrahydrofuran; mineral oil;
at -78 - 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/ol502016h
- Guidance literature:
-
With
N-Methyldicyclohexylamine; palladium diacetate; tetra-(n-butyl)ammonium iodide; tri tert-butylphosphoniumtetrafluoroborate;
In
methanol; toluene;
at 130 ℃;
for 0.333333h;
under 7500.75 Torr;
DOI:10.1002/cctc.201200778
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / diethyl ether; hexane / 0.33 h / -78 °C / Inert atmosphere
1.2: 0.17 h / -78 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / -30 °C / Inert atmosphere
2.2: 3 h / -78 - 20 °C / Inert atmosphere
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran; diethyl ether; hexane; mineral oil;
2.1: |Wittig Olefination / 2.2: |Wittig Olefination;
DOI:10.1021/ol502016h
