ALPHA-(AMINOMETHYL)-5-METHOXY-1H-INDOLE-3-ACETIC ACID METHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: ALPHA-(AMINOMETHYL)-5-METHOXY-1H-INDOLE-3-ACETIC ACID METHYL ESTER HYDROCHLORIDE
• CAS No.: 72318-55-9
• Molecular Formula: C₁₃H₁₆N₂O₃*ClH
• Molecular Weight: 284.743
• Mol file: 72318-55-9.mol

Synonyms:1H-Indole-3-aceticacid, a-(aminomethyl)-5-methoxy-, methylester, monohydrochloride (9CI); Indorenate hydrochloride; TR 3369

Chemical Property of ALPHA-(AMINOMETHYL)-5-METHOXY-1H-INDOLE-3-ACETIC ACID METHYL ESTER HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 4.89E-08mmHg at 25°C
• Boiling Point: 442.8°C at 760 mmHg
• Flash Point: 221.6°C
• PSA: 77.34000
• LogP: 2.89410
• Storage Temp.: Desiccate at RT

Purity/Quality:

97% ^*data from raw suppliers

IndorenateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antihypertensive. Indorenate Hydrochloride is a 5-HT receptor agonist. A serotoninergic anti-hypertensive agent.

Technology Process of ALPHA-(AMINOMETHYL)-5-METHOXY-1H-INDOLE-3-ACETIC ACID METHYL ESTER HYDROCHLORIDE

There total 14 articles about ALPHA-(AMINOMETHYL)-5-METHOXY-1H-INDOLE-3-ACETIC ACID METHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 2-(5-methoxy-1H-indol-3-yl)-3-nitropropanoate → methyl 3-Amino-2-(5-methoxy-1H-indol-3-yl)propanoate Hydrochloride (72318-55-9)

Guidance literature:

With hydrogenchloride; zinc; In tetrahydrofuran; methanol; for 2h; Inert atmosphere; Reflux;

DOI:10.1021/acs.jmedchem.7b01593

Reference yield: 84.0%

→ methyl 3-Amino-2-(5-methoxy-1H-indol-3-yl)propanoate Hydrochloride (72318-55-9)

Guidance literature:

With hydrogenchloride; copper(II) sulfate; zinc; In tetrahydrofuran; methanol; water; for 2h; Electric arc;

Reference yield: 77.0%

methanol (67-56-1) + 3-amino-2-(5-methoxy-1H-indol-3-yl)-propanoic acid (73139-82-9) → methyl 3-Amino-2-(5-methoxy-1H-indol-3-yl)propanoate Hydrochloride (72318-55-9)

Guidance literature:

With hydrogenchloride; thionyl chloride; In 1,4-dioxane; methanol; at -10 - 21 ℃; for 18h; SOCl₂ adding to a pre-cooled susp. of the acid in MeOH, stirring under Ar, evapg., treated with aq. K₂CO₃ and with 4 N HCl;

DOI:10.1111/j.2042-7158.1997.tb06789.x

upstream raw materials:

3-amino-2-(5-methoxy-1H-indol-3-yl)-propanoic acid

methanol

5-methoxylindole

5-methoxyindole-3-acetonitrile

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