6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline

Base Information

Chemical Name:6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline
CAS No.:442517-38-6
Molecular Formula:C₂₀H₁₉N₅O₂
Molecular Weight:361.403
Hs Code.:
Mol file:442517-38-6.mol

Synonyms:6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline;Quinoxaline, 6-[2-(diMethoxyMethyl)-5-(6-Methyl-2-pyridinyl)-1H-iMidazol-4-yl]-

Suppliers and Price of 6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 5 raw suppliers

Chemical Property of 6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline

Chemical Property:

PSA：85.81000
LogP:3.68170

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline

There total 4 articles about 6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 364050-21-5
1-(6-methylpyridin-2-yl)-2-(quinoxalin-6-yl)ethane-1,2-dione

: 51673-84-8
dimethoxyacetaldehyde

: 631-61-8,92206-38-7
ammonium acetate

: 442517-38-6
2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazole

Guidance literature:: In methanol; water; at 20 ℃; for 3h;
DOI:10.1021/jm070129k

Reference yield:

: 108-48-5
2,6-dimethylpyridine

: 442517-38-6
2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -60 °C

1.2: Et₂AlCl / tetrahydrofuran; hexane / -60 - 20 °C

1.3: 65 percent / tetrahydrofuran; hexane / 0.33 h / -60 °C

2.1: 66 percent / DMSO; aq. HBr / 2 h / 60 - 70 °C

3.1: 83 percent / various solvent(s); methanol; H₂O / 3 h / 20 °C

With n-butyllithium; hydrogen bromide; dimethyl sulfoxide; In tetrahydrofuran; methanol; hexane; water;
DOI:10.1021/jm070129k

Reference yield:

: 356560-90-2
2-(6-methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone

: 442517-38-6
2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / DMSO; aq. HBr / 2 h / 60 - 70 °C

2: 83 percent / various solvent(s); methanol; H₂O / 3 h / 20 °C

With hydrogen bromide; dimethyl sulfoxide; In methanol; water;
DOI:10.1021/jm070129k