3-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE

Base Information

• Chemical Name: 3-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE
• CAS No.: 78318-00-0
• Molecular Formula: C15H15N
• Molecular Weight: 209.291
• Hs Code.: 2933499090
• Mol file: 78318-00-0.mol

Synonyms:3-Phenyl-1,2,3,4-tetrahydro-isochinolin;3-phenyl-1,2,3,4-tetrahydro-isoquinoline;

Chemical Property of 3-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE

Chemical Property:

• PSA: 12.03000
• LogP: 3.40240

Purity/Quality:

3-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE

There total 13 articles about 3-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3,4-dihydro-3-phenylisoquinoline (135365-20-7) → 3-phenyl-1,2,3,4-tetrahydroisoquinoline (78318-00-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 3h;

DOI:10.1002/ejoc.201900238

Reference yield:

acetophenonazine (729-43-1) → 1,2,3,4-tetrahydroisoquinoline (91-21-4) + Isopropylbenzene (98-82-8) + 3-Methyl-4,5-diphenylpyrazole (51463-88-8) + 3-phenyl-1,2,3,4-tetrahydroisoquinoline (78318-00-0) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6)

Guidance literature:

at 320 - 350 ℃; Product distribution; Mechanism; Sealed glass ampul;

DOI:10.1007/BF00522730

Reference yield:

1-chloro-3-phenylisoquinoline (55150-54-4) → 3-phenyl-1,2,3,4-tetrahydroisoquinoline (78318-00-0)

Guidance literature:

With sodium amalgam; ethanol;

upstream raw materials:

1-chloro-3-phenylisoquinoline

1,4-dichloro-3-phenyl-isoquinoline

2-formyl-1,2,3,4-tetrahydro-3-phenylisoquinoline

ethanol

Downstream raw materials:

[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-(3-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-amine

2-amino-3-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

Refernces

• 1、 Foubelo,Gomez,Gutierrez,Yus. "Synthesis of substituted tetrahydroisoquinolines and benzo[d]azepines from phthalan or isochroman and N-silylaldimines". . p. 1061 - 1064. Retrieved 2007/10/03.
• 2、 -. "Chemotherapeutic agents". . . Retrieved 2008/06/13.