886041-65-2Relevant academic research and scientific papers
Development of a scalable chiral synthesis of MK-3281, an inhibitor of the hepatitis C virus NS5B polymerase
Colarusso, Stefania,Conte, Immacolata,Di Filippo, Marcello,Ercolani, Caterina,MacKay, Angela C.,Palumbi, Maria Cecilia,Rico Ferreira, Maria Del Rosario,Stansfield, Ian,Zaramella, Simone,Narjes, Frank,Habermann, J?rg
, p. 1527 - 1532 (2011/08/03)
The development of a scalable chiral synthesis for the HCV NS5B inhibitor MK-3281 is being reported. Several alternative routes were explored and are being described. Georg Thieme Verlag Stuttgart ? New York.
Discovery of (7 R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6 H -indolo[1,2- e ][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase
Narjes, Frank,Crescenzi, Benedetta,Ferrara, Marco,Habermann, J?rg,Colarusso, Stefania,Del Rosario Rico Ferreira, Maria,Stansfield, Ian,MacKay, Angela Claire,Conte, Immacolata,Ercolani, Caterina,Zaramella, Simone,Palumbi, Maria-Cecilia,Meuleman, Philip,Leroux-Roels, Geert,Giuliano, Claudio,Fiore, Fabrizio,Di Marco, Stefania,Baiocco, Paola,Koch, Uwe,Migliaccio, Giovanni,Altamura, Sergio,Laufer, Ralph,De Francesco, Raffaele,Rowley, Michael
, p. 289 - 301 (2011/03/22)
Infections caused by hepatitis C virus (HCV) are a significant world health problem for which novel therapies are in urgent demand. The polymerase of HCV is responsible for the replication of viral genome and has been a prime target for drug discovery eff
TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS
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Page/Page column 34, (2010/11/08)
The present invention relates to tetracyclic indole compounds of formula (I); wherein R1, R2, A, Ar, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
