1-(4-(Benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)ethanone

Base Information

• Chemical Name: 1-(4-(Benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)ethanone
• CAS No.: 889675-05-2
• Molecular Formula: C23H19NO4S
• Molecular Weight: 405.474
• Hs Code.: 2933990090
• Mol file: 889675-05-2.mol

Synonyms:1-(4-(benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)ethanone;

Chemical Property of 1-(4-(Benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)ethanone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 621.178°C at 760 mmHg
• Flash Point: 329.477°C
• PSA: 73.75000
• Density: 1.257g/cm³
• LogP: 5.74070
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

1-(4-(Benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-(Benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)ethanone

There total 4 articles about 1-(4-(Benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

acetic anhydride (108-24-7) + 4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole (79315-62-1) → 1-(4-(benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)ethanone (889675-05-2)

Guidance literature:

4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;

acetic anhydride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 12.5h;

DOI:10.1021/jm060136t

Reference yield:

1H-indol-4-ol (2380-94-1) → 1-(4-(benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)ethanone (889675-05-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 94 percent / K₂CO₃ / acetone / 72 h / Heating

2.1: NaH / dimethylformamide / 0.08 h / 0 °C

2.2: 80 percent / dimethylformamide / 0.5 h / 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

3.2: 89 percent / hexane; tetrahydrofuran / 12.5 h / -78 - 20 °C

With n-butyllithium; sodium hydride; potassium carbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm060136t

Reference yield:

4-benzyloxy-1H-indole (20289-26-3) → 1-(4-(benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl)ethanone (889675-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.08 h / 0 °C

1.2: 80 percent / dimethylformamide / 0.5 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

2.2: 89 percent / hexane; tetrahydrofuran / 12.5 h / -78 - 20 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1021/jm060136t

upstream raw materials:

acetic anhydride

4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole

1H-indol-4-ol

4-benzyloxy-1H-indole

Downstream raw materials:

((3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)acetic acid

1-benzyl-2-ethyl-1H-indol-4-ol

tert-butyl 2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate

tert-butyl 2-(1-benzyl-2-ethyl-1H-indol-4-yloxy)acetate

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