N-(6-BroMo-naphthalen-2-yl)MethanesulfonaMide

Base Information

• Chemical Name: N-(6-BroMo-naphthalen-2-yl)MethanesulfonaMide
• CAS No.: 1132940-86-3
• Molecular Formula: C11H10BrNO2S
• Molecular Weight: 300.176
• Hs Code.: 2935009090
• Mol file: 1132940-86-3.mol

Synonyms:N-(6-BroMo-naphthalen-2-yl)MethanesulfonaMide;Methanesulfonamide, N-(6-bromo-2-naphthalenyl)-

Chemical Property of N-(6-BroMo-naphthalen-2-yl)MethanesulfonaMide

Chemical Property:

• Boiling Point: 441.4±37.0 °C(Predicted)
• PKA: 8.21±0.30(Predicted)
• PSA: 54.55000
• Density: 1.665±0.06 g/cm3(Predicted)
• LogP: 4.12760
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

N-(6-Bromonaphthalen-2-yl)methanesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(6-Bromonaphthalen-2-yl)methanesulfonamide is used as a reactant in the synthesis of arylpyrimidinediones as hepatitis C virus inhibitors.

Technology Process of N-(6-BroMo-naphthalen-2-yl)MethanesulfonaMide

There total 5 articles about N-(6-BroMo-naphthalen-2-yl)MethanesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-Bromonaphthalen-2-amine (7499-66-3) + methanesulfonyl chloride (124-63-0) → N-(6-bromonaphthalen-2-yl)-methanesulfonamide (1132940-86-3)

Guidance literature:

With pyridine; In tetrahydrofuran; at 5 ℃;

DOI:10.1021/op4003467

Reference yield: 94.0%

6-bromo-2-aminonaphthalene hydrochloride (71590-31-3) + methanesulfonyl chloride (124-63-0) → N-(6-bromonaphthalen-2-yl)-methanesulfonamide (1132940-86-3)

Guidance literature:

With pyridine; In dichloromethane; at 5 ℃; for 3h;

Reference yield:

6-bromo-2-oximino-1,2,3,4-tetrahydronaphthalene (133277-09-5) → N-(6-bromonaphthalen-2-yl)-methanesulfonamide (1132940-86-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; hydrogenchloride

2: pyridine / 2-methyltetrahydrofuran

With pyridine; hydrogenchloride; acetic acid; In 2-methyltetrahydrofuran;

DOI:10.1021/acs.joc.8b02690

upstream raw materials:

6-Bromonaphthalen-2-amine

methanesulfonyl chloride

6-bromo-2-aminonaphthalene hydrochloride

6-bromo-2-oximino-1,2,3,4-tetrahydronaphthalene

Downstream raw materials:

N-[6-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)naphthalen-2-yl]methanesulfonamide

N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide

N-(naphthalen-2-yl)methanesulfonamide

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