4-Bromo-2-methoxy-6-methylpyridine

Base Information

• Chemical Name: 4-Bromo-2-methoxy-6-methylpyridine
• CAS No.: 1083169-00-9
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.051
• Hs Code.: 2933399090
• Mol file: 1083169-00-9.mol

Synonyms:4-BROMO-2-METHOXY-6-METHYLPYRIDINE;Pyridine, 4-bromo-2-methoxy-6-methyl-

Chemical Property of 4-Bromo-2-methoxy-6-methylpyridine

Chemical Property:

• PSA: 22.12000
• LogP: 2.16110
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-2-methoxy-6-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2-methoxy-6-methylpyridine

There total 2 articles about 4-Bromo-2-methoxy-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

methanol (67-56-1) + 2-hydroxy-4-bromo-6-methylpyridine (865156-59-8) → 4-bromo-2-methoxy-6-methylpyridine (1083169-00-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

4-hydroxy-6-methyl-2-pyridone (3749-51-7,4664-15-7) → 4-bromo-2-methoxy-6-methylpyridine (1083169-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus(V) oxybromide / N,N-dimethyl-formamide / 1 h / 110 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 h / 20 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; phosphorus(V) oxybromide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 82.0%

4-bromo-2-methoxy-6-methylpyridine (1083169-00-9) + tert-butyl (3S)-3-aminopiperidine-1-carboxylate (625471-18-3) → C17H27N3O3

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; tert-butyl XPhos; In 1,4-dioxane; at 95 - 100 ℃; for 0.5h; Inert atmosphere; Sealed tube;

upstream raw materials:

methanol

2-hydroxy-4-bromo-6-methylpyridine

4-hydroxy-6-methyl-2-pyridone

Downstream raw materials:

2-methoxy-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine