(4,6-Dimethylpyridin-2-yl)methanol

Base Information

• Chemical Name: (4,6-Dimethylpyridin-2-yl)methanol
• CAS No.: 18087-99-5
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 2933399090
• European Community (EC) Number: 878-009-1
• DSSTox Substance ID: DTXSID50401684
• Nikkaji Number: J1.436.816G
• Mol file: 18087-99-5.mol

Synonyms:(4,6-dimethylpyridin-2-yl)methanol;18087-99-5;2-Pyridinemethanol, 4,6-dimethyl-;4,6-Dimethyl-2-pyridinemethanol;MFCD00956273;(4,6-dimethyl-pyridin-2-yl)-methanol;SCHEMBL667378;DTXSID50401684;VKQZCYMDNLIADD-UHFFFAOYSA-N;(4,6-dimethyl-2-pyridinyl)methanol;AKOS016004672;AB87705;4,6-Dimethyl-2-(hydroxymethyl)pyridine;AS-47106;SY065707;CS-0153162;EN300-186826;F12065;J-011548

Chemical Property of (4,6-Dimethylpyridin-2-yl)methanol

Chemical Property:

• PSA: 33.12000
• LogP: 1.19070
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

96% ^*data from raw suppliers

(4,6-Dimethylpyridin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=C1)CO)C

Technology Process of (4,6-Dimethylpyridin-2-yl)methanol

There total 12 articles about (4,6-Dimethylpyridin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4,6-dimethylpyridine-2-carboxylic acid ethyl ester (80206-42-4) → 4,6-dimethyl-2-(hydroxymethyl)pyridine (18087-99-5)

Guidance literature:

4,6-dimethylpyridine-2-carboxylic acid ethyl ester; With sodium tetrahydroborate; In ethanol; at 20 ℃; for 48h; Inert atmosphere;

With hydrogenchloride; In ethanol; water; for 1h; Inert atmosphere;

DOI:10.1002/adsc.201200938

Reference yield: 71.0%

→ 4,6-dimethyl-2-(hydroxymethyl)pyridine (18087-99-5)

Guidance literature:

Reference yield: 50.0%

2,4,6-trimethyl-pyridine 1-oxide (3376-50-9) → 4,6-dimethyl-2-(hydroxymethyl)pyridine (18087-99-5)

Guidance literature:

With trifluoroacetic anhydride; at 0 - 20 ℃; for 5h;

upstream raw materials:

1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate

methanol

2,4-dimethylpyridine N-oxide

2,4,6-trimethyl-pyridine

Downstream raw materials:

4,6-dimethylpyridine-2-carboxylic acid

4,6-dimethylpyridine-2-carbaldehyde

(4,6-dimethylpyridin-2-ylmethyl)(4-nitrophenyl)amine