4,6-Dimethylpicolinic acid

Base Information

• Chemical Name: 4,6-Dimethylpicolinic acid
• CAS No.: 18088-10-3
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90351210
• Nikkaji Number: J149.549F
• Wikidata: Q82127428
• Mol file: 18088-10-3.mol

Synonyms:4,6-Dimethylpicolinic acid;18088-10-3;4,6-dimethylpyridine-2-carboxylic Acid;2-Pyridinecarboxylicacid, 4,6-dimethyl-;2-Pyridinecarboxylicacid,4,6-dimethyl-(9CI);MFCD04113826;4,6-Dimethylpicolinicacid;4,6-DIMETHYL-2-PYRIDINECARBOXYLIC ACID;2-PYRIDINECARBOXYLIC ACID, 4,6-DIMETHYL-;SCHEMBL668136;DTXSID90351210;DYOKWPWMTZHTPS-UHFFFAOYSA-N;AMY18924;AKOS000273262;AB17859;FS-3452;4.6-dimethyl-2-pyridinecarboxylic acid;2-pyridinecarboxylic acid,4,6-dimethyl-;CS-0204920;FT-0756373;EN300-111559;Y10195;2-PYRIDINECARBOXYLIC ACID 4,6-DIMETHYL-;F3099-7193

Chemical Property of 4,6-Dimethylpicolinic acid

Chemical Property:

• Vapor Pressure: 0.000463mmHg at 25°C
• Refractive Index: 1.553
• Boiling Point: 301.6°C at 760 mmHg
• Flash Point: 136.2°C
• PSA: 50.19000
• Density: 1.183g/cm³
• LogP: 1.39660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 158

Purity/Quality:

98%min ^*data from raw suppliers

4,6-Dimethylpicolinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=C1)C(=O)O)C

Technology Process of 4,6-Dimethylpicolinic acid

There total 12 articles about 4,6-Dimethylpicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,6-dimethyl-2-(hydroxymethyl)pyridine (18087-99-5) → 4,6-dimethylpyridine-2-carboxylic acid (18088-10-3)

Guidance literature:

With potassium permanganate; In water; at 0 - 20 ℃; for 1.5h;

Reference yield:

2,4-dimethylpyridine N-oxide (1122-45-8) → 4,6-dimethylpyridine-2-carboxylic acid (18088-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-Dimethylcarbamoyl chloride / dichloromethane / Inert atmosphere

2: water; potassium hydroxide / 4 h / Reflux

With water; potassium hydroxide; N,N-Dimethylcarbamoyl chloride; In dichloromethane;

DOI:10.1002/adsc.201200938

Reference yield:

2,4-lutidine (108-47-4) → 4,6-dimethylpyridine-2-carboxylic acid (18088-10-3)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; dihydrogen peroxide / 24 h / Reflux

2: N,N-Dimethylcarbamoyl chloride / dichloromethane / Inert atmosphere

3: water; potassium hydroxide / 4 h / Reflux

With water; dihydrogen peroxide; acetic acid; potassium hydroxide; N,N-Dimethylcarbamoyl chloride; In dichloromethane;

DOI:10.1002/adsc.201200938

upstream raw materials:

2,4,6-trimethyl-pyridine

4,6-dimethylpyridine-2-carbaldehyde

2,4-dimethyl-6-styryl-pyridine

2-(4,6-dimethylpyridin-2-yl)ethanol

Downstream raw materials:

4,6-dimethylpyridine-2-carbaldehyde

2-Amino-4,6-dimethylpyridine

4,6-dimethylpicolinamide

2,4-lutidine

Refernces

• 1、 -. "Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex". Page/Page column 40. . Retrieved 2008/06/13.